Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1886040..1886669 Replicon chromosome
Accession NZ_HF545616
Organism Ruminococcus bicirculans strain 80/3

Toxin (Protein)


Gene name hicA Uniprot ID W0U7D1
Locus tag RBI_RS08720 Protein ID WP_038672383.1
Coordinates 1886040..1886222 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID W0U6I9
Locus tag RBI_RS08725 Protein ID WP_038672386.1
Coordinates 1886259..1886669 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RBI_RS08705 1881422..1883926 + 2505 WP_038672377.1 type IV secretory system conjugative DNA transfer family protein -
RBI_RS08710 1883913..1884659 + 747 WP_038672379.1 helix-turn-helix domain-containing protein -
RBI_RS08715 1884876..1885958 + 1083 WP_038672381.1 site-specific integrase -
RBI_RS08720 1886040..1886222 + 183 WP_038672383.1 type II toxin-antitoxin system HicA family toxin Toxin
RBI_RS08725 1886259..1886669 + 411 WP_038672386.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
RBI_RS08730 1886716..1886988 + 273 WP_038672388.1 helix-turn-helix domain-containing protein -
RBI_RS08740 1888224..1890398 + 2175 WP_022287606.1 anaerobic ribonucleoside-triphosphate reductase -
RBI_RS08745 1890654..1891172 + 519 WP_038672390.1 anaerobic ribonucleoside-triphosphate reductase activating protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1842415..1887850 45435


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-101)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6758.83 Da        Isoelectric Point: 10.4719

>T284941 WP_038672383.1 NZ_HF545616:1886040-1886222 [Ruminococcus bicirculans]
MTFKEMDRLLKEAGWYYDGARGSHFKYKHKSQNGIVIVPNHKGDIPKGTANAILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15165.36 Da        Isoelectric Point: 4.2253

>AT284941 WP_038672386.1 NZ_HF545616:1886259-1886669 [Ruminococcus bicirculans]
MLSMYPACFYKEKEGGYSVIFPVLGIATCGDDINQAMSMAVDCLAGYLYELKLSKEEVPAAPDMDKIDIDAEYNDYESAF
VNMVTVDVDEYAKKHFEKSVKKTLTIPSWLNELAVANGINFSQVLQTALKDKLNVN

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0U7D1

Antitoxin

Source ID Structure
AlphaFold DB W0U6I9

References