Detailed information of TA system TA284939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5264567..5266248
• Replicon: chromosome
• Accession: NZ_FO834906
• Organism: Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: BN49_RS27100
• Protein ID: WP_004146663.1
• Coordinates: 5264567..5265484 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W9BJR4
• Locus tag: BN49_RS27105
• Protein ID: WP_016531766.1
• Coordinates: 5265490..5266248 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN49_RS27080	5259873..5261393	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
BN49_RS27085	5261390..5262388	+	999	WP_002885172.1	ribose ABC transporter permease	-
BN49_RS27090	5262419..5263360	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
BN49_RS27095	5263435..5264442	+	1008	WP_004221949.1	carbohydrate kinase family protein	-
BN49_RS27100	5264567..5265484	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
BN49_RS27105	5265490..5266248	-	759	WP_016531766.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
BN49_RS27110	5266334..5267062	-	729	WP_004177810.1	response regulator transcription factor	-
BN49_RS27125	5267335..5269482	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
BN49_RS27130	5269712..5270398	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T284939 WP_004146663.1 NZ_FO834906:c5265484-5264567 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28476.86 Da
• Isoelectric Point: 10.1683

>AT284939 WP_016531766.1 NZ_FO834906:c5266248-5265490 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFRGFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: W9BJR4