Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5106290..5106806 Replicon chromosome
Accession NZ_FO834906
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag BN49_RS26260 Protein ID WP_002886902.1
Coordinates 5106290..5106574 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag BN49_RS26265 Protein ID WP_002886901.1
Coordinates 5106564..5106806 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS26230 5101686..5101994 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
BN49_RS31220 5102079..5102252 + 174 WP_002886906.1 hypothetical protein -
BN49_RS26240 5102255..5102998 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
BN49_RS26250 5103355..5105493 + 2139 WP_046043947.1 anaerobic ribonucleoside-triphosphate reductase -
BN49_RS26255 5105822..5106286 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BN49_RS26260 5106290..5106574 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BN49_RS26265 5106564..5106806 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BN49_RS26270 5106884..5108794 - 1911 WP_004152270.1 BglG family transcription antiterminator -
BN49_RS26275 5108817..5109971 - 1155 WP_004178372.1 lactonase family protein -
BN49_RS26280 5110038..5110778 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T284938 WP_002886902.1 NZ_FO834906:c5106574-5106290 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT284938 WP_002886901.1 NZ_FO834906:c5106806-5106564 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References