Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4976664..4977289 Replicon chromosome
Accession NZ_FO834906
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag BN49_RS25635 Protein ID WP_002882817.1
Coordinates 4976664..4977047 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag BN49_RS25640 Protein ID WP_004150355.1
Coordinates 4977047..4977289 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS25620 4974030..4974932 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
BN49_RS25625 4974929..4975564 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
BN49_RS25630 4975561..4976490 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
BN49_RS25635 4976664..4977047 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
BN49_RS25640 4977047..4977289 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
BN49_RS25645 4977491..4978408 + 918 WP_004178029.1 alpha/beta hydrolase -
BN49_RS25650 4978422..4979363 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
BN49_RS25655 4979408..4979845 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
BN49_RS25660 4979842..4980702 - 861 WP_002882807.1 virulence factor BrkB family protein -
BN49_RS25665 4980696..4981295 - 600 WP_046043904.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T284936 WP_002882817.1 NZ_FO834906:c4977047-4976664 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT284936 WP_004150355.1 NZ_FO834906:c4977289-4977047 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References