Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2883987..2885575 Replicon chromosome
Accession NZ_FO834906
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name hipA Uniprot ID W9B834
Locus tag BN49_RS15675 Protein ID WP_016529318.1
Coordinates 2884253..2885575 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BN49_RS15670 Protein ID WP_004176198.1
Coordinates 2883987..2884253 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS15645 2879110..2880033 + 924 WP_016529218.1 LysR family hpxDE operon transcriptional regulator HpxR -
BN49_RS15650 2880014..2881168 - 1155 WP_046043281.1 FAD-dependent urate hydroxylase HpxO -
BN49_RS15655 2881514..2882893 + 1380 WP_004176204.1 purine permease -
BN49_RS15660 2882871..2883371 + 501 WP_046043283.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
BN49_RS15665 2883368..2883694 + 327 WP_002904788.1 hydroxyisourate hydrolase -
BN49_RS15670 2883987..2884253 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
BN49_RS15675 2884253..2885575 + 1323 WP_016529318.1 type II toxin-antitoxin system HipA family toxin Toxin
BN49_RS15680 2885592..2886884 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
BN49_RS15685 2887026..2888030 - 1005 WP_009308876.1 type 1 fimbrial protein -
BN49_RS15690 2888018..2890519 - 2502 Protein_2814 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iroE / mgtC 2849116..3065122 216006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5366

>T284931 WP_016529318.1 NZ_FO834906:2884253-2885575 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT284931 WP_004176198.1 NZ_FO834906:2883987-2884253 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B834

Antitoxin

Source ID Structure

References