Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1457780..1458399 Replicon chromosome
Accession NZ_FO834906
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag BN49_RS08490 Protein ID WP_002892050.1
Coordinates 1457780..1457998 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag BN49_RS08495 Protein ID WP_002892066.1
Coordinates 1458025..1458399 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS08455 1453827..1454090 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
BN49_RS08460 1454090..1454230 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
BN49_RS08465 1454227..1454925 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
BN49_RS08470 1455026..1456477 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
BN49_RS08475 1456452..1456922 - 471 WP_002892026.1 YlaC family protein -
BN49_RS30910 1456943..1457083 + 141 WP_004147370.1 hypothetical protein -
BN49_RS08485 1457055..1457621 - 567 WP_002892030.1 maltose O-acetyltransferase -
BN49_RS08490 1457780..1457998 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
BN49_RS08495 1458025..1458399 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
BN49_RS08500 1458885..1462031 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
BN49_RS08505 1462054..1463247 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T284930 WP_002892050.1 NZ_FO834906:c1457998-1457780 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT284930 WP_002892066.1 NZ_FO834906:c1458399-1458025 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References