Detailed information of TA system TA028493

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1401384..1402000
• Replicon: chromosome
• Accession: NC_019676
• Organism: Nostoc sp. PCC 7107

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K9Q9R1
• Locus tag: NOS7107_RS06025
• Protein ID: WP_015112092.1
• Coordinates: 1401384..1401773 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K9QAP6
• Locus tag: NOS7107_RS06030
• Protein ID: WP_015112093.1
• Coordinates: 1401770..1402000 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOS7107_RS06005	1397257..1398339	-	1083	WP_015112088.1	photosystem II q(b) protein	-
NOS7107_RS06010	1398673..1399251	-	579	WP_015112089.1	Uma2 family endonuclease	-
NOS7107_RS06015	1399274..1399846	-	573	WP_015112090.1	Uma2 family endonuclease	-
NOS7107_RS06020	1399967..1401094	-	1128	WP_015112091.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
NOS7107_RS06025	1401384..1401773	-	390	WP_015112092.1	type II toxin-antitoxin system VapC family toxin	Toxin
NOS7107_RS06030	1401770..1402000	-	231	WP_015112093.1	DUF2281 domain-containing protein	Antitoxin
NOS7107_RS06035	1402331..1403335	+	1005	WP_015112094.1	hypothetical protein	-
NOS7107_RS06040	1403423..1404194	+	772	Protein_1190	CHAT domain-containing protein	-
NOS7107_RS27150	1406537..1406776	-	240	WP_157373975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

• Domain of unknown function DUF2281 (6-74)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14546.66 Da
• Isoelectric Point: 4.6248

>T28493 WP_015112092.1 NC_019676:c1401773-1401384 [Nostoc sp. PCC 7107]
MSNFLLDTHAFIWLTENDSNLRDDLRAIIDNADVVYLSIASLWEIAIKLKLGKLSLQSSYETIGSAIEASDILILGISFD
DTVLVCNLPLHHGDPFDRMLIAQAVNHSLIIVSRDTKFDAYTNVHRMWT

Nucleotide

• Length: 390 bp

>T28493 NC_019676:c1401773-1401384 [Nostoc sp. PCC 7107]
ATGAGTAATTTTCTGTTAGATACTCATGCCTTTATCTGGCTGACTGAAAATGACTCTAACCTTAGAGATGATCTGAGGGC
GATAATTGATAACGCAGATGTGGTTTATCTAAGCATAGCTAGTCTTTGGGAAATTGCTATCAAATTAAAACTTGGCAAAT
TATCATTGCAAAGCAGCTATGAAACTATAGGTTCTGCAATTGAAGCTTCAGATATTCTCATATTGGGAATCTCGTTTGAT
GATACAGTTTTAGTCTGTAATCTTCCGCTACATCATGGTGATCCATTTGATCGGATGCTAATCGCACAGGCGGTTAATCA
CTCCTTAATTATCGTTAGTAGGGATACAAAATTTGATGCTTATACTAATGTTCACCGAATGTGGACATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8927.12 Da
• Isoelectric Point: 4.4354

>AT28493 WP_015112093.1 NC_019676:c1402000-1401770 [Nostoc sp. PCC 7107]
MTVDTEILQTLEQMPEPLKQELLHYAKYLVENYSKTSSQDSSLRKKRRSGILKGTFILPLPDDFDEPLSDFQEYME

Nucleotide

• Length: 231 bp

>AT28493 NC_019676:c1402000-1401770 [Nostoc sp. PCC 7107]
ATGACTGTTGATACAGAAATTTTACAAACACTAGAGCAAATGCCAGAGCCACTAAAACAAGAACTCTTGCATTATGCCAA
ATATTTAGTTGAGAATTATTCAAAAACTAGTTCTCAGGACAGTTCATTACGAAAAAAGCGCCGTTCTGGCATCTTAAAAG
GCACTTTTATTTTACCTTTACCGGATGATTTTGATGAACCTCTCTCAGATTTTCAGGAATATATGGAATGA

Structures

Toxin

• AlphaFold DB: K9Q9R1

Antitoxin

• AlphaFold DB: K9QAP6