Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 109386..110137 Replicon plasmid II
Accession NZ_FO834905
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name ataT Uniprot ID W9BA31
Locus tag BN49_RS01090 Protein ID WP_032104592.1
Coordinates 109386..109868 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID W9B1S8
Locus tag BN49_RS01095 Protein ID WP_016529519.1
Coordinates 109859..110137 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS28480 105483..105935 + 453 WP_071829949.1 transcriptional repressor -
BN49_RS01070 106083..107315 + 1233 Protein_112 IS3 family transposase -
BN49_RS01075 107700..107936 + 237 WP_016529523.1 hypothetical protein -
BN49_RS01080 108002..108607 - 606 Protein_114 GIY-YIG nuclease family protein -
BN49_RS01085 108944..109348 - 405 WP_016529521.1 DUF2251 domain-containing protein -
BN49_RS01090 109386..109868 - 483 WP_032104592.1 GNAT family N-acetyltransferase Toxin
BN49_RS01095 109859..110137 - 279 WP_016529519.1 DUF1778 domain-containing protein Antitoxin
BN49_RS01100 110445..110981 + 537 WP_032445791.1 hypothetical protein -
BN49_RS01105 111365..112375 - 1011 WP_004152284.1 zinc-binding alcohol dehydrogenase family protein -
BN49_RS01115 112836..113918 + 1083 WP_016528990.1 DNA-binding transcriptional repressor LacI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA 1..121703 121703


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17781.73 Da        Isoelectric Point: 9.4946

>T284923 WP_032104592.1 NZ_FO834905:c109868-109386 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10708.23 Da        Isoelectric Point: 4.5156

>AT284923 WP_016529519.1 NZ_FO834905:c110137-109859 [Klebsiella pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BA31

Antitoxin

Source ID Structure
AlphaFold DB W9B1S8

References