Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 85561..86096 Replicon plasmid I
Accession NZ_FO834904
Organism Klebsiella pneumoniae strain Kp52.145

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BN49_RS00500 Protein ID WP_016531292.1
Coordinates 85561..85848 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W9BAK2
Locus tag BN49_RS00505 Protein ID WP_016531291.1
Coordinates 85845..86096 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN49_RS00475 81360..82580 - 1221 WP_032446666.1 ISL3 family transposase -
BN49_RS00480 82741..83217 + 477 WP_016529487.1 hypothetical protein -
BN49_RS00485 83474..83761 - 288 WP_016529486.1 hypothetical protein -
BN49_RS00490 83851..84513 - 663 WP_016529485.1 chromosome partitioning protein ParA -
BN49_RS00500 85561..85848 - 288 WP_016531292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BN49_RS00505 85845..86096 - 252 WP_016531291.1 toxin-antitoxin stability system antitoxin protein StbD Antitoxin
BN49_RS00510 86192..87463 - 1272 WP_046041953.1 Y-family DNA polymerase -
BN49_RS00515 87463..87957 - 495 WP_109234271.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
BN49_RS00520 87943..89022 + 1080 WP_016531016.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - clbI / basG 1..95087 95087
- flank IS/Tn - - 81360..82580 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11120.16 Da        Isoelectric Point: 10.4373

>T284921 WP_016531292.1 NZ_FO834904:c85848-85561 [Klebsiella pneumoniae]
MTYTVKFREDALKEWNKLDKTIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDNQLIIAIVAVGK
RERSDVYTLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.68 Da        Isoelectric Point: 4.2257

>AT284921 WP_016531291.1 NZ_FO834904:c86096-85845 [Klebsiella pneumoniae]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELIKLVAERSNQPLFDMDLE
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W9BAK2

References