Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3912716..3914399 Replicon chromosome
Accession NZ_FO818637
Organism Xenorhabdus bovienii strain CS03

Toxin (Protein)


Gene name mosT Uniprot ID A0A0B6XC08
Locus tag XBW1_RS17905 Protein ID WP_046337508.1
Coordinates 3912716..3913633 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A077N7D9
Locus tag XBW1_RS17910 Protein ID WP_038202374.1
Coordinates 3913626..3914399 (-) Length 258 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XBW1_RS17890 3908708..3910276 - 1569 WP_046337505.1 phosphoethanolamine transferase -
XBW1_RS17895 3910770..3911375 + 606 WP_046337506.1 plasmid pRiA4b ORF-3 family protein -
XBW1_RS17900 3911562..3912599 + 1038 WP_046337507.1 IS630 family transposase -
XBW1_RS17905 3912716..3913633 - 918 WP_046337508.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
XBW1_RS17910 3913626..3914399 - 774 WP_038202374.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
XBW1_RS17915 3914727..3915155 - 429 WP_038216214.1 IS200/IS605 family transposase -
XBW1_RS17920 3915615..3915827 + 213 WP_012989909.1 RNA chaperone/antiterminator CspA -
XBW1_RS17925 3916146..3916331 - 186 Protein_3589 Fic family protein -
XBW1_RS17935 3916718..3916987 + 270 WP_046337510.1 transposase -
XBW1_RS24175 3916966..3917139 + 174 WP_082243360.1 hypothetical protein -
XBW1_RS24180 3917192..3918033 + 842 WP_155399205.1 IS5 family transposase -
XBW1_RS24860 3918058..3918330 + 273 Protein_3593 IS1 family transposase -
XBW1_RS17950 3918355..3918825 + 471 WP_046337511.1 SCP2 sterol-binding domain-containing protein -
XBW1_RS17955 3919001..3919387 + 387 WP_051875985.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3910770..3924602 13832


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(19-276)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34600.68 Da        Isoelectric Point: 4.8558

>T284914 WP_046337508.1 NZ_FO818637:c3913633-3912716 [Xenorhabdus bovienii]
MDKYSPYYRQVALLISALLVVASERCFALKGGTAINLFVRDFPRLSVDIDLVYVPLESRDVALANVRAALTRITGLLQQQ
VGVSAILQTNNHDEMRIIVSSQEAQIKIEVSPVARGTLYPSQDLDVAEAVEDEFGFATIQVVSMADLYGGKLCAALDRQH
PRDLYDVKMLLETQGIDRHIFNGFITYLLSHPRPLSEVLNPRWKDISELYAHEFSGMTFDNVSLEELNVVPEFMISALKS
QFTQQDFDFLISFKSGEPDWQLVPESQIQHLPAVKWKLHNIGRIPEEKHIQALEKLERVLNDWMG

Download         Length: 918 bp

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 29293.73 Da        Isoelectric Point: 9.8753

>AT284914 WP_038202374.1 NZ_FO818637:c3914399-3913626 [Xenorhabdus bovienii]
MSSKLNWLLQNTAPGSLVLQSWLTKHGISPSLANKYMHSNWLQKLRTGVYVRAGRDPEWWDVVLCLQNQLGFPVHLAGLT
SLGYQGRSHYLQFKQQAIWLYVQDKAALPKWFKEFPNIEWLLLSNQKLAKHDEKYLTEVEIKGEQLRTSVPELAAYEIAN
AVPGILSFEHAAELFQGLVNLSPRKVEALLQSSRAVQTNRLYLFLADYYAHAWAKRLDQTNIDLGAGKRQIVSGGKLDRK
YQITVPEKFVSHGLLHG

Download         Length: 774 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B6XC08

Antitoxin

Source ID Structure
AlphaFold DB A0A077N7D9

References