Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 3828645..3829496 Replicon chromosome
Accession NZ_FO818637
Organism Xenorhabdus bovienii strain CS03

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag XBW1_RS17515 Protein ID WP_082243358.1
Coordinates 3828645..3829022 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XBW1_RS17520 Protein ID WP_038204870.1
Coordinates 3829026..3829496 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XBW1_RS17490 3823718..3824623 + 906 WP_046337466.1 hypothetical protein -
XBW1_RS17495 3824724..3825182 + 459 WP_046337467.1 hypothetical protein -
XBW1_RS17500 3825376..3826068 - 693 WP_038222751.1 O-methyltransferase -
XBW1_RS17505 3826209..3827225 - 1017 WP_012989845.1 UDP-glucose 4-epimerase GalE -
XBW1_RS17510 3827438..3828178 + 741 WP_046337468.1 4'-phosphopantetheinyl transferase superfamily protein -
XBW1_RS17515 3828645..3829022 + 378 WP_082243358.1 type II toxin-antitoxin system HigB family toxin Toxin
XBW1_RS17520 3829026..3829496 + 471 WP_038204870.1 transcriptional regulator Antitoxin
XBW1_RS17525 3829544..3830095 - 552 WP_038204872.1 3-isopropylmalate dehydratase -
XBW1_RS17530 3830092..3831390 - 1299 WP_046337469.1 3-isopropylmalate dehydratase large subunit -
XBW1_RS17535 3831680..3832600 + 921 WP_046337470.1 LysR family transcriptional regulator -
XBW1_RS17540 3832663..3833442 - 780 WP_038197005.1 Sua5/YciO/YrdC/YwlC family protein -
XBW1_RS17545 3833498..3833983 - 486 WP_038213357.1 YbhB/YbcL family Raf kinase inhibitor-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(75-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(98-152)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 15035.55 Da        Isoelectric Point: 10.6216

>T284913 WP_082243358.1 NZ_FO818637:3828645-3829022 [Xenorhabdus bovienii]
MRVRVITARVIIEVMRKHAQWKVGLKLWLDVFDKAALRFESYAQIRDLWLQTSAWNVDRIPHELLEAGNQKGPLDIYIFD
IHKNKCRIIAWLNPKSGTFYIKDVCSHAKYDRWWREQTKSNRPKR

Download         Length: 378 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17848.57 Da        Isoelectric Point: 4.7275

>AT284913 WP_038204870.1 NZ_FO818637:3829026-3829496 [Xenorhabdus bovienii]
MRQALLVYEEIDGIIKKLPQMMQSVSDQLSPLALLFSACLEPVENEEDLKARMVIIDELYSYADDTEHVAAKFADFVTDR
IYEYETKNRNVSNVSPREALAFFMKERRIRQADLCDIATQSVISEILHGKRSMTIQQVKGFAKFFGVPVETFMGTL

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References