Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2929699..2930344 Replicon chromosome
Accession NZ_FO704551
Organism Xenorhabdus poinarii G6

Toxin (Protein)


Gene name hicA Uniprot ID A0A068R5W8
Locus tag XPG1_RS13615 Protein ID WP_045959536.1
Coordinates 2930171..2930344 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A068R6X7
Locus tag XPG1_RS13610 Protein ID WP_045959535.1
Coordinates 2929699..2930115 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XPG1_RS13595 2924724..2926472 + 1749 WP_045959533.1 DNA primase -
XPG1_RS13600 2926807..2928657 + 1851 WP_045959534.1 RNA polymerase sigma factor RpoD -
XPG1_RS13610 2929699..2930115 - 417 WP_045959535.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
XPG1_RS13615 2930171..2930344 - 174 WP_045959536.1 type II toxin-antitoxin system HicA family toxin Toxin
XPG1_RS17750 2930464..2930883 - 420 WP_157879568.1 hypothetical protein -
XPG1_RS13625 2930805..2931191 + 387 WP_157879504.1 type II toxin-antitoxin system HicB family antitoxin -
XPG1_RS13630 2931542..2932639 + 1098 WP_071825386.1 glycosyltransferase family 9 protein -
XPG1_RS13635 2932892..2934274 + 1383 WP_045960769.1 cysteine--tRNA ligase -
XPG1_RS17755 2934417..2934653 - 237 WP_071825387.1 stationary-phase-induced ribosome-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6652.78 Da        Isoelectric Point: 11.1572

>T284907 WP_045959536.1 NZ_FO704551:c2930344-2930171 [Xenorhabdus poinarii G6]
VKQSEFRRWLEAQGVEVSNGTNHLKLKYQGKRSIMPRHPSQELKEPLRKAIIKQLGL

Download         Length: 174 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15469.59 Da        Isoelectric Point: 4.3332

>AT284907 WP_045959535.1 NZ_FO704551:c2930115-2929699 [Xenorhabdus poinarii G6]
MRYPVTLEPVEEGGYFVSFPDIPEALTQGETREEALEMALDALITSFEFYFEDNEKIPLPRSVGRDDDYVDVPLSVASKV
LMLNAFVDSKLTQTELASRMGVKKQEVTRIFDLRHSTKIDTVGKVATAIGHQLTLSIE

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068R5W8

Antitoxin

Source ID Structure
AlphaFold DB A0A068R6X7

References