Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1371319..1371963 Replicon chromosome
Accession NZ_FO704551
Organism Xenorhabdus poinarii G6

Toxin (Protein)


Gene name hicA Uniprot ID A0A068R2A5
Locus tag XPG1_RS06340 Protein ID WP_045958322.1
Coordinates 1371778..1371963 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A068R4K5
Locus tag XPG1_RS06335 Protein ID WP_045958321.1
Coordinates 1371319..1371732 (-) Length 138 a.a.

Genomic Context

XPG1_RS06295XPG1_RS06300XPG1_RS17985XPG1_RS06310XPG1_RS06315XPG1_RS06320XPG1_RS17465XPG1_RS06330XPG1_RS06345XPG1_RS06350XPG1_RS06355XPG1_RS06360XPG1_RS06335XPG1_RS06340
Location: 1367079..1367408 (330 bp)
Type: Others
Protein ID: WP_045960298.1
Location: 1367405..1367800 (396 bp)
Type: Others
Protein ID: WP_045958315.1
Location: 1367809..1368258 (450 bp)
Type: Others
Protein ID: WP_084717349.1
Location: 1368255..1368479 (225 bp)
Type: Others
Protein ID: WP_045958317.1
Location: 1368959..1369150 (192 bp)
Type: Others
Protein ID: WP_045960535.1
Location: 1369198..1369434 (237 bp)
Type: Others
Protein ID: WP_045958318.1
Location: 1369446..1370066 (621 bp)
Type: Others
Protein ID: WP_045958319.1
Location: 1370047..1371276 (1230 bp)
Type: Others
Protein ID: WP_045958320.1
Location: 1372074..1373576 (1503 bp)
Type: Others
Protein ID: WP_045958323.1
Location: 1373614..1374327 (714 bp)
Type: Others
Protein ID: WP_045958324.1
Location: 1374324..1375607 (1284 bp)
Type: Others
Protein ID: WP_045958325.1
Location: 1375607..1376104 (498 bp)
Type: Others
Protein ID: WP_045958326.1
Location: 1371319..1371732 (414 bp)
Type: Antitoxin
Protein ID: WP_045958321.1
Location: 1371778..1371963 (186 bp)
Type: Toxin
Protein ID: WP_045958322.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XPG1_RS062951367079..1367408+330WP_045960298.1phage holin, lambda family-
XPG1_RS063001367405..1367800+396WP_045958315.1structural protein-
XPG1_RS179851367809..1368258+450WP_084717349.1lysis protein-
XPG1_RS063101368255..1368479+225WP_045958317.1hypothetical protein-
XPG1_RS063151368959..1369150+192WP_045960535.1hypothetical protein-
XPG1_RS063201369198..1369434+237WP_045958318.1hypothetical protein-
XPG1_RS174651369446..1370066+621WP_045958319.1terminase small subunit-
XPG1_RS063301370047..1371276+1230WP_045958320.1PBSX family phage terminase large subunit-
XPG1_RS063351371319..1371732-414WP_045958321.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
XPG1_RS063401371778..1371963-186WP_045958322.1type II toxin-antitoxin system HicA family toxinToxin
XPG1_RS063451372074..1373576+1503WP_045958323.1DUF1073 domain-containing protein-
XPG1_RS063501373614..1374327+714WP_045958324.1head protein-
XPG1_RS063551374324..1375607+1284WP_045958325.1DUF2213 domain-containing protein-
XPG1_RS063601375607..1376104+498WP_045958326.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1346677..138992243245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7062.30 Da        Isoelectric Point: 10.9659

>T284905 WP_045958322.1 NZ_FO704551:c1371963-1371778 [Xenorhabdus poinarii G6]
MKSSELIKLLEKNGWVLDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQILKNAKLKN

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15345.19 Da        Isoelectric Point: 4.5264

>AT284905 WP_045958321.1 NZ_FO704551:c1371732-1371319 [Xenorhabdus poinarii G6]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADAISAINAHFELLSEKGFDIPSPKSQQTHLMNSINDYKNGVWF
LVDIDIDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A068R2A5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A068R4K5

References