Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 986875..987529 Replicon chromosome
Accession NZ_FO704551
Organism Xenorhabdus poinarii G6

Toxin (Protein)


Gene name hicA Uniprot ID A0A068R1A1
Locus tag XPG1_RS04550 Protein ID WP_045958023.1
Coordinates 987353..987529 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A068R3H8
Locus tag XPG1_RS04545 Protein ID WP_045958022.1
Coordinates 986875..987291 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XPG1_RS04520 984241..984636 + 396 WP_045958017.1 antitermination protein Q -
XPG1_RS04525 985287..985472 + 186 WP_045958018.1 phage holin family protein -
XPG1_RS04530 985453..985992 + 540 WP_045958019.1 lysozyme -
XPG1_RS17955 986116..986556 + 441 WP_157879537.1 lysis protein -
XPG1_RS04540 986553..986777 + 225 WP_045958021.1 hypothetical protein -
XPG1_RS04545 986875..987291 - 417 WP_045958022.1 transcriptional regulator Antitoxin
XPG1_RS04550 987353..987529 - 177 WP_045958023.1 type II toxin-antitoxin system HicA family toxin Toxin
XPG1_RS04555 987637..988209 + 573 WP_045958024.1 terminase small subunit -
XPG1_RS04560 988214..989833 + 1620 WP_045958025.1 bacteriophage TerL protein -
XPG1_RS04565 989833..991521 + 1689 WP_045958026.1 DUF1073 domain-containing protein -
XPG1_RS04570 991409..992131 + 723 WP_173425860.1 minor capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 966993..1018979 51986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(9-75)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6650.82 Da        Isoelectric Point: 10.6309

>T284904 WP_045958023.1 NZ_FO704551:c987529-987353 [Xenorhabdus poinarii G6]
VKQSEFLKWLKAHGVETENGKKHLKLYYKGKISHLPRHPSQELTTGLVEGIKKQLGLK

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15639.00 Da        Isoelectric Point: 4.3660

>AT284904 WP_045958022.1 NZ_FO704551:c987291-986875 [Xenorhabdus poinarii G6]
MYYPAEFVKEDNGYTVTFRDIPEAITCGTDMPEAMEMAEDVLLSCVEIYFDMDKNFPLPNSEIQEDEQWVYLPDSVYAKI
LLNNELLKANINKAELSRLTGIRPPEIQRILAPRHATKIDTISRAVAAIGKKLSLSVI

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068R1A1

Antitoxin

Source ID Structure
AlphaFold DB A0A068R3H8

References