Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 986875..987529 Replicon chromosome
Accession NZ_FO704551
Organism Xenorhabdus poinarii G6

Toxin (Protein)


Gene name hicA Uniprot ID A0A068R1A1
Locus tag XPG1_RS04550 Protein ID WP_045958023.1
Coordinates 987353..987529 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A068R3H8
Locus tag XPG1_RS04545 Protein ID WP_045958022.1
Coordinates 986875..987291 (-) Length 139 a.a.

Genomic Context

XPG1_RS04520XPG1_RS04525XPG1_RS04530XPG1_RS17955XPG1_RS04540XPG1_RS04555XPG1_RS04560XPG1_RS04565XPG1_RS04570XPG1_RS04545XPG1_RS04550
Location: 984241..984636 (396 bp)
Type: Others
Protein ID: WP_045958017.1
Location: 985287..985472 (186 bp)
Type: Others
Protein ID: WP_045958018.1
Location: 985453..985992 (540 bp)
Type: Others
Protein ID: WP_045958019.1
Location: 986116..986556 (441 bp)
Type: Others
Protein ID: WP_157879537.1
Location: 986553..986777 (225 bp)
Type: Others
Protein ID: WP_045958021.1
Location: 987637..988209 (573 bp)
Type: Others
Protein ID: WP_045958024.1
Location: 988214..989833 (1620 bp)
Type: Others
Protein ID: WP_045958025.1
Location: 989833..991521 (1689 bp)
Type: Others
Protein ID: WP_045958026.1
Location: 991409..992131 (723 bp)
Type: Others
Protein ID: WP_173425860.1
Location: 986875..987291 (417 bp)
Type: Antitoxin
Protein ID: WP_045958022.1
Location: 987353..987529 (177 bp)
Type: Toxin
Protein ID: WP_045958023.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XPG1_RS04520984241..984636+396WP_045958017.1antitermination protein Q-
XPG1_RS04525985287..985472+186WP_045958018.1phage holin family protein-
XPG1_RS04530985453..985992+540WP_045958019.1lysozyme-
XPG1_RS17955986116..986556+441WP_157879537.1lysis protein-
XPG1_RS04540986553..986777+225WP_045958021.1hypothetical protein-
XPG1_RS04545986875..987291-417WP_045958022.1transcriptional regulatorAntitoxin
XPG1_RS04550987353..987529-177WP_045958023.1type II toxin-antitoxin system HicA family toxinToxin
XPG1_RS04555987637..988209+573WP_045958024.1terminase small subunit-
XPG1_RS04560988214..989833+1620WP_045958025.1bacteriophage TerL protein-
XPG1_RS04565989833..991521+1689WP_045958026.1DUF1073 domain-containing protein-
XPG1_RS04570991409..992131+723WP_173425860.1minor capsid protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--966993..101897951986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(9-75)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6650.82 Da        Isoelectric Point: 10.6309

>T284904 WP_045958023.1 NZ_FO704551:c987529-987353 [Xenorhabdus poinarii G6]
VKQSEFLKWLKAHGVETENGKKHLKLYYKGKISHLPRHPSQELTTGLVEGIKKQLGLK

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15639.00 Da        Isoelectric Point: 4.3660

>AT284904 WP_045958022.1 NZ_FO704551:c987291-986875 [Xenorhabdus poinarii G6]
MYYPAEFVKEDNGYTVTFRDIPEAITCGTDMPEAMEMAEDVLLSCVEIYFDMDKNFPLPNSEIQEDEQWVYLPDSVYAKI
LLNNELLKANINKAELSRLTGIRPPEIQRILAPRHATKIDTISRAVAAIGKKLSLSVI

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A068R1A1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A068R3H8

References