Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4112611..4113386 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A068QX71
Locus tag XDD1_RS17950 Protein ID WP_045973188.1
Coordinates 4112611..4113111 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A068QXP5
Locus tag XDD1_RS17955 Protein ID WP_045973189.1
Coordinates 4113108..4113386 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XDD1_RS17925 4107743..4108291 - 549 WP_084721077.1 AMP-binding protein -
XDD1_RS17930 4108598..4109071 + 474 WP_045973186.1 helix-turn-helix domain-containing protein -
XDD1_RS17935 4109065..4109601 + 537 WP_084720900.1 IS630 family transposase -
XDD1_RS17940 4109951..4111249 + 1299 WP_084721079.1 hypothetical protein -
XDD1_RS17945 4112048..4112491 + 444 WP_045973187.1 OsmC family protein -
XDD1_RS17950 4112611..4113111 - 501 WP_045973188.1 GNAT family N-acetyltransferase Toxin
XDD1_RS17955 4113108..4113386 - 279 WP_045973189.1 DUF1778 domain-containing protein Antitoxin
XDD1_RS17960 4113466..4114248 - 783 WP_045973190.1 pimeloyl-ACP methyl ester esterase BioH -
XDD1_RS17965 4114292..4114975 + 684 WP_045973191.1 DNA utilization protein GntX -
XDD1_RS17970 4115035..4115610 + 576 WP_045973192.1 Fe-S biogenesis protein NfuA -
XDD1_RS17975 4115775..4116098 + 324 WP_045973193.1 thiosulfate sulfurtransferase GlpE -
XDD1_RS17980 4116165..4117004 + 840 WP_045973194.1 rhomboid family intramembrane serine protease GlpG -
XDD1_RS17985 4117100..4117858 + 759 WP_045973195.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(21-145)

Antitoxin

Vibrio phage ICP1, Orf50

(9-83)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18192.20 Da        Isoelectric Point: 8.4793

>T284901 WP_045973188.1 NZ_FO704550:c4113111-4112611 [Xenorhabdus doucetiae]
MIISEPKLLADYHHLESFDSGVVTFDQWLKNRALKNNLTGASKTYVVCDENRVMAYYSLAASAIVMGSAPGHFKRNMPNP
IPVVVLGRLAVDRRLQRKGIGRALVKDAALRVIQAADLIGVRGMIIHALSDEAKSFYEATGFEPSPLDPMLLMATLMDLK
SACTDS

Download         Length: 501 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10522.18 Da        Isoelectric Point: 6.3492

>AT284901 WP_045973189.1 NZ_FO704550:c4113386-4113108 [Xenorhabdus doucetiae]
MQTTKRDTLNIRIKPEIRNLIDRAAAIQGKNRTDFMLEAARRMAEETLIEQAIITASPEAYAEFLARLDMPPQPNKPLQA
TLQMETPWGKEL

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068QX71

Antitoxin

Source ID Structure
AlphaFold DB A0A068QXP5

References