Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /BrnT(toxin) |
| Location | 1702721..1703201 | Replicon | chromosome |
| Accession | NC_019675 | ||
| Organism | Cyanobium gracile PCC 6307 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | K9P8L8 |
| Locus tag | CYAGR_RS08275 | Protein ID | WP_015109349.1 |
| Coordinates | 1702938..1703201 (-) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | K9P7G8 |
| Locus tag | CYAGR_RS08270 | Protein ID | WP_015109348.1 |
| Coordinates | 1702721..1702951 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CYAGR_RS08220 | 1697810..1698112 | - | 303 | WP_043325591.1 | hypothetical protein | - |
| CYAGR_RS08225 | 1698112..1698420 | - | 309 | WP_015109341.1 | DUF86 domain-containing protein | - |
| CYAGR_RS08230 | 1698461..1698727 | - | 267 | WP_015109342.1 | nucleotidyltransferase domain-containing protein | - |
| CYAGR_RS18720 | 1698934..1699143 | - | 210 | WP_043325593.1 | addiction module protein | - |
| CYAGR_RS08240 | 1699298..1699699 | - | 402 | WP_015109344.1 | type II toxin-antitoxin system VapC family toxin | - |
| CYAGR_RS08245 | 1699699..1699947 | - | 249 | WP_043325596.1 | ribbon-helix-helix domain-containing protein | - |
| CYAGR_RS17780 | 1699933..1700559 | + | 627 | WP_083891437.1 | HNH endonuclease | - |
| CYAGR_RS17060 | 1700573..1700806 | - | 234 | WP_015109346.1 | DUF4926 domain-containing protein | - |
| CYAGR_RS08255 | 1701216..1701764 | + | 549 | WP_043325598.1 | HNH endonuclease | - |
| CYAGR_RS08260 | 1701860..1702153 | - | 294 | WP_071881570.1 | hypothetical protein | - |
| CYAGR_RS08265 | 1702211..1702480 | - | 270 | WP_043325600.1 | prevent-host-death protein | - |
| CYAGR_RS08270 | 1702721..1702951 | - | 231 | WP_015109348.1 | hypothetical protein | Antitoxin |
| CYAGR_RS08275 | 1702938..1703201 | - | 264 | WP_015109349.1 | BrnT family toxin | Toxin |
| CYAGR_RS18280 | 1703476..1703919 | + | 444 | WP_043325604.1 | hypothetical protein | - |
| CYAGR_RS08285 | 1704133..1704366 | - | 234 | WP_015109350.1 | addiction module protein | - |
| CYAGR_RS18725 | 1704504..1704671 | + | 168 | WP_172637167.1 | hypothetical protein | - |
| CYAGR_RS18730 | 1704693..1705037 | + | 345 | Protein_1700 | HNH endonuclease | - |
| CYAGR_RS18735 | 1705062..1705461 | + | 400 | Protein_1701 | HIT family protein | - |
| CYAGR_RS08295 | 1705512..1706453 | + | 942 | WP_015109351.1 | HNH endonuclease | - |
| CYAGR_RS17085 | 1706465..1706671 | - | 207 | WP_015109352.1 | hypothetical protein | - |
| CYAGR_RS18285 | 1706631..1707050 | - | 420 | WP_156818424.1 | BrnT family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1698112..1726916 | 28804 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10058.45 Da Isoelectric Point: 5.6939
>T28490 WP_015109349.1 NC_019675:c1703201-1702938 [Cyanobium gracile PCC 6307]
MEFVFDPLKSDSSLAKHGIDFLAAQQLWNDSELLELPARTTGEPRSLVIGRIGLKHWSAVITYRDQSIRLISVRRSRPEE
VELYEQF
MEFVFDPLKSDSSLAKHGIDFLAAQQLWNDSELLELPARTTGEPRSLVIGRIGLKHWSAVITYRDQSIRLISVRRSRPEE
VELYEQF
Download Length: 264 bp
>T28490 NC_019675:c1703201-1702938 [Cyanobium gracile PCC 6307]
ATGGAGTTCGTGTTCGATCCGCTCAAGAGTGACTCCAGCCTTGCCAAGCACGGCATCGACTTCCTTGCTGCCCAGCAGCT
CTGGAACGATTCGGAGCTCCTGGAGCTTCCGGCCCGCACCACCGGGGAACCGAGATCTCTGGTGATCGGCAGGATTGGCC
TCAAGCACTGGTCAGCCGTGATCACTTACCGCGACCAGAGCATCCGATTGATTTCCGTTCGGCGGTCCAGACCAGAAGAG
GTGGAGCTCTATGAACAGTTCTGA
ATGGAGTTCGTGTTCGATCCGCTCAAGAGTGACTCCAGCCTTGCCAAGCACGGCATCGACTTCCTTGCTGCCCAGCAGCT
CTGGAACGATTCGGAGCTCCTGGAGCTTCCGGCCCGCACCACCGGGGAACCGAGATCTCTGGTGATCGGCAGGATTGGCC
TCAAGCACTGGTCAGCCGTGATCACTTACCGCGACCAGAGCATCCGATTGATTTCCGTTCGGCGGTCCAGACCAGAAGAG
GTGGAGCTCTATGAACAGTTCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8785.92 Da Isoelectric Point: 6.3203
>AT28490 WP_015109348.1 NC_019675:c1702951-1702721 [Cyanobium gracile PCC 6307]
MNSSDFDQRFDAGESVLDALDLGGARRRRLEQKRVNVDIPVWMIDQLDREASRLGVTRQSIIKVWLAERLEQRTSA
MNSSDFDQRFDAGESVLDALDLGGARRRRLEQKRVNVDIPVWMIDQLDREASRLGVTRQSIIKVWLAERLEQRTSA
Download Length: 231 bp
>AT28490 NC_019675:c1702951-1702721 [Cyanobium gracile PCC 6307]
ATGAACAGTTCTGATTTCGATCAACGTTTCGATGCCGGCGAGTCCGTGCTCGACGCCCTCGACCTCGGTGGTGCCCGTCG
CCGTCGGCTCGAGCAGAAACGCGTCAACGTTGACATCCCCGTGTGGATGATCGACCAGCTCGATCGCGAAGCCAGCCGCC
TCGGCGTCACCCGTCAGTCGATCATCAAGGTGTGGCTCGCGGAGCGGCTGGAGCAGCGGACGTCTGCTTGA
ATGAACAGTTCTGATTTCGATCAACGTTTCGATGCCGGCGAGTCCGTGCTCGACGCCCTCGACCTCGGTGGTGCCCGTCG
CCGTCGGCTCGAGCAGAAACGCGTCAACGTTGACATCCCCGTGTGGATGATCGACCAGCTCGATCGCGAAGCCAGCCGCC
TCGGCGTCACCCGTCAGTCGATCATCAAGGTGTGGCTCGCGGAGCGGCTGGAGCAGCGGACGTCTGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|