Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 3336851..3337699 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name relE Uniprot ID A0A068QW26
Locus tag XDD1_RS14510 Protein ID WP_045972272.1
Coordinates 3337328..3337699 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XDD1_RS14505 Protein ID WP_052705726.1
Coordinates 3336851..3337324 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XDD1_RS14490 3331883..3333037 - 1155 WP_045972266.1 methionine adenosyltransferase -
XDD1_RS14495 3333467..3335371 + 1905 WP_045972268.1 biosynthetic arginine decarboxylase -
XDD1_RS14500 3335739..3336665 + 927 WP_045972270.1 agmatinase -
XDD1_RS14505 3336851..3337324 - 474 WP_052705726.1 transcriptional regulator Antitoxin
XDD1_RS14510 3337328..3337699 - 372 WP_045972272.1 type II toxin-antitoxin system HigB family toxin Toxin
XDD1_RS14515 3337781..3338533 - 753 WP_045972274.1 4'-phosphopantetheinyl transferase superfamily protein -
XDD1_RS14520 3338684..3339703 + 1020 WP_045972276.1 UDP-glucose 4-epimerase GalE -
XDD1_RS14525 3339806..3340894 + 1089 WP_045972278.1 UDP-glucose--hexose-1-phosphate uridylyltransferase -
XDD1_RS14530 3340933..3342087 + 1155 WP_045972280.1 galactokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(73-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(99-153)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14835.25 Da        Isoelectric Point: 10.3075

>T284898 WP_045972272.1 NZ_FO704550:c3337699-3337328 [Xenorhabdus doucetiae]
MRVITAKTITEAMQKHAQWKVGLKLWLDVFDKVSLRFESYAQIRELWLNTSTWNVDRVPYELLEAESKKGPLDIYVFDIH
KNKCRIITWLNPKSGTFYIKDVCPHSEYDKWWRKQTKSKRSKR

Download         Length: 372 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17767.27 Da        Isoelectric Point: 4.4249

>AT284898 WP_052705726.1 NZ_FO704550:c3337324-3336851 [Xenorhabdus doucetiae]
MRKTSLVTYEGIDGLIEILPQMMQSISEQLGPLALLFSACIEPVENDEDLNARMALIDELYSYAENTEHAAAKFADLITD
RVYEYEAKNRQVPNVIPREALSYFMREKGVRQIDLRDIASQSVISEILHGKRSMNIGQVKGFAQFFNVPVETFMGSD

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068QW26

Antitoxin

Source ID Structure

References