Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2463623..2464659 | Replicon | chromosome |
| Accession | NZ_FO704550 | ||
| Organism | Xenorhabdus doucetiae strain FRM16 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A068QTP5 |
| Locus tag | XDD1_RS10710 | Protein ID | WP_045971068.1 |
| Coordinates | 2463623..2464198 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A068QSM1 |
| Locus tag | XDD1_RS10715 | Protein ID | WP_045971070.1 |
| Coordinates | 2464198..2464659 (-) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XDD1_RS10675 | 2458932..2459408 | + | 477 | WP_045971056.1 | flagellar biosynthetic protein FliO | - |
| XDD1_RS10680 | 2459455..2460192 | + | 738 | WP_148885917.1 | flagellar type III secretion system pore protein FliP | - |
| XDD1_RS10685 | 2460255..2460524 | + | 270 | WP_045971058.1 | flagellar biosynthesis protein FliQ | - |
| XDD1_RS10690 | 2460527..2461309 | + | 783 | WP_045971060.1 | flagellar type III secretion system protein FliR | - |
| XDD1_RS10695 | 2461306..2462064 | - | 759 | WP_045971062.1 | SDR family oxidoreductase | - |
| XDD1_RS10700 | 2462412..2463092 | - | 681 | WP_045971064.1 | winged helix-turn-helix domain-containing protein | - |
| XDD1_RS10705 | 2463167..2463478 | + | 312 | WP_045971066.1 | antibiotic biosynthesis monooxygenase | - |
| XDD1_RS10710 | 2463623..2464198 | - | 576 | WP_045971068.1 | PIN domain-containing protein | Toxin |
| XDD1_RS10715 | 2464198..2464659 | - | 462 | WP_045971070.1 | helix-turn-helix domain-containing protein | Antitoxin |
| XDD1_RS10720 | 2464904..2465851 | - | 948 | WP_045971072.1 | flagellar hook-associated protein FlgL | - |
| XDD1_RS10725 | 2465901..2467538 | - | 1638 | WP_045971074.1 | flagellar hook-associated protein FlgK | - |
| XDD1_RS10730 | 2467628..2468635 | - | 1008 | WP_197541026.1 | flagellar assembly peptidoglycan hydrolase FlgJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21717.23 Da Isoelectric Point: 5.5480
>T284897 WP_045971068.1 NZ_FO704550:c2464198-2463623 [Xenorhabdus doucetiae]
MTHSPYPVLLDACVLYPARLRDLLMHLGLCGLYQPKWTVDIHEEWKRNLLINRSDLTVEQLNRVQMLMDRALPDANVIGY
DLLIPSINLIDKNDRHVLAAAIQANAEIIVTYNLKDFPADYLSTFGIEAFHPDDFVSDIIDLNHAISLQSINNLRNSLKK
PPLTIEEFLASLSQIGMAKTVKALESYKFML
MTHSPYPVLLDACVLYPARLRDLLMHLGLCGLYQPKWTVDIHEEWKRNLLINRSDLTVEQLNRVQMLMDRALPDANVIGY
DLLIPSINLIDKNDRHVLAAAIQANAEIIVTYNLKDFPADYLSTFGIEAFHPDDFVSDIIDLNHAISLQSINNLRNSLKK
PPLTIEEFLASLSQIGMAKTVKALESYKFML
Download Length: 576 bp
Antitoxin
Download Length: 154 a.a. Molecular weight: 17175.69 Da Isoelectric Point: 6.6449
>AT284897 WP_045971070.1 NZ_FO704550:c2464659-2464198 [Xenorhabdus doucetiae]
MTTTTLPNIQLPDTQEKEIAQKSYRDLSALLATKFEARHFTIKNDEKEGQSIEVPSSAVKLLVEILGELACGNAVQIVPV
HAELTTQEAANILNVSRPHVVKLLEDGQIKFHKTGRHRRIRFADLMAFKQKRDADAMLAMDELTSLSQDYGIY
MTTTTLPNIQLPDTQEKEIAQKSYRDLSALLATKFEARHFTIKNDEKEGQSIEVPSSAVKLLVEILGELACGNAVQIVPV
HAELTTQEAANILNVSRPHVVKLLEDGQIKFHKTGRHRRIRFADLMAFKQKRDADAMLAMDELTSLSQDYGIY
Download Length: 462 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A068QTP5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A068QSM1 |