Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 936350..936932 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name PumA Uniprot ID A0A068QNS5
Locus tag XDD1_RS04445 Protein ID WP_045973327.1
Coordinates 936350..936646 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag XDD1_RS04450 Protein ID WP_045969068.1
Coordinates 936648..936932 (+) Length 95 a.a.

Genomic Context

XDD1_RS04415XDD1_RS04420XDD1_RS04435XDD1_RS04440XDD1_RS04445XDD1_RS04450XDD1_RS04425XDD1_RS04430XDD1_RS04455XDD1_RS04460XDD1_RS19715XDD1_RS04475XDD1_RS04480XDD1_RS19720
Location: 931436..931672 (237 bp)
Type: Others
Protein ID: WP_045969060.1
Location: 931852..934488 (2637 bp)
Type: Others
Protein ID: WP_045969062.1
Location: 935439..935768 (330 bp)
Type: Others
Protein ID: WP_038262604.1
Location: 935909..936247 (339 bp)
Type: Others
Protein ID: WP_045969066.1
Location: 936350..936646 (297 bp)
Type: Toxin
Protein ID: WP_045973327.1
Location: 936648..936932 (285 bp)
Type: Antitoxin
Protein ID: WP_045969068.1
Location: 934520..934945 (426 bp)
Type: Others
Protein ID: WP_045969064.1
Location: 934945..935199 (255 bp)
Type: Others
Protein ID: WP_038262601.1
Location: 936995..937378 (384 bp)
Type: Others
Protein ID: WP_045969070.1
Location: 937705..938184 (480 bp)
Type: Others
Protein ID: WP_045969072.1
Location: 938538..939859 (1322 bp)
Type: Others
Protein ID: Protein_855
Location: 940142..940564 (423 bp)
Type: Others
Protein ID: WP_045969076.1
Location: 940561..940980 (420 bp)
Type: Others
Protein ID: WP_045969078.1
Location: 941208..941432 (225 bp)
Type: Others
Protein ID: WP_197541013.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XDD1_RS04415931436..931672+237WP_045969060.1helix-turn-helix domain-containing protein-
XDD1_RS04420931852..934488+2637WP_045969062.1host specificity protein J-
XDD1_RS04425934520..934945-426WP_045969064.1type II toxin-antitoxin system VapC family toxin-
XDD1_RS04430934945..935199-255WP_038262601.1type II toxin-antitoxin system Phd/YefM family antitoxin-
XDD1_RS04435935439..935768+330WP_038262604.1type I toxin-antitoxin system SymE family toxin-
XDD1_RS04440935909..936247+339WP_045969066.1SymE family type I addiction module toxin-
XDD1_RS04445936350..936646+297WP_045973327.1type II toxin-antitoxin system RelE/ParE family toxinToxin
XDD1_RS04450936648..936932+285WP_045969068.1putative addiction module antidote proteinAntitoxin
XDD1_RS04455936995..937378-384WP_045969070.1hypothetical protein-
XDD1_RS04460937705..938184-480WP_045969072.1hypothetical protein-
XDD1_RS19715938538..939859-1322Protein_855RHS repeat protein-
XDD1_RS04475940142..940564-423WP_045969076.1hypothetical protein-
XDD1_RS04480940561..940980-420WP_045969078.1hypothetical protein-
XDD1_RS19720941208..941432-225WP_197541013.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--930472..96213331661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11258.93 Da        Isoelectric Point: 7.9975

>T284896 WP_045973327.1 NZ_FO704550:936350-936646 [Xenorhabdus doucetiae]
MITIERTQDFEKWLKSLKDRIAKTKILIRVERMEEGNFGDVEPVGSGVSELKIHDGQGYRVYFANKNNEIILLLCGGDKS
SQQEDIKKAKQLAKEWGF

Download         Length: 297 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10502.92 Da        Isoelectric Point: 5.8648

>AT284896 WP_045969068.1 NZ_FO704550:936648-936932 [Xenorhabdus doucetiae]
MKSEPKKFDVVEFLETEDDIQAYLNAAIEENDTKYLFKALGNIARIKNISQLSKESGISREGIYKALSDEGNPSFNTVYK
ISKALGLKLHFTGA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A068QNS5

Antitoxin

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Source
ID
Structure
No matching records found

References