Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 872940..873559 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name Hha Uniprot ID A0A068QNM5
Locus tag XDD1_RS04160 Protein ID WP_045968972.1
Coordinates 872940..873143 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A068QNR7
Locus tag XDD1_RS04165 Protein ID WP_045968974.1
Coordinates 873191..873559 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XDD1_RS04140 868383..868721 + 339 WP_045968966.1 P-II family nitrogen regulator -
XDD1_RS04145 868734..870014 + 1281 WP_045968968.1 ammonium transporter AmtB -
XDD1_RS04150 870093..870923 - 831 WP_045968970.1 acyl-CoA thioesterase II -
XDD1_RS04155 870920..871964 - 1045 Protein_794 IS630 family transposase -
XDD1_RS04160 872940..873143 - 204 WP_045968972.1 hemolysin expression modulator Hha Toxin
XDD1_RS04165 873191..873559 - 369 WP_045968974.1 Hha toxicity modulator TomB Antitoxin
XDD1_RS04170 874189..877338 - 3150 WP_045968976.1 multidrug efflux RND transporter permease subunit -
XDD1_RS04175 877353..878552 - 1200 WP_045968978.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 870920..871579 659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8033.33 Da        Isoelectric Point: 7.9892

>T284895 WP_045968972.1 NZ_FO704550:c873143-872940 [Xenorhabdus doucetiae]
MTKTDYLMRLRKCTSIETLERVIEKNKYELSADELELFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14430.29 Da        Isoelectric Point: 5.4884

>AT284895 WP_045968974.1 NZ_FO704550:c873559-873191 [Xenorhabdus doucetiae]
MDEYSPRRHDVAELKYLCENLIHEAFSVLNRTDNHWIHDLTSEKSLKLNELIEHIAAFVWSFKIKYSDNYTLSTLIDNYL
DETYNLFGSDKISFLELTKWQKTNEHLTNILLHDLNAALSKI

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068QNM5

Antitoxin

Source ID Structure
AlphaFold DB A0A068QNR7

References