Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 795149..795788 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag XDD1_RS03830 Protein ID WP_045968846.1
Coordinates 795606..795788 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A068QNK7
Locus tag XDD1_RS03825 Protein ID WP_045968844.1
Coordinates 795149..795553 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XDD1_RS03810 790810..792432 + 1623 WP_045968838.1 peptide ABC transporter substrate-binding protein -
XDD1_RS03815 792570..793016 - 447 WP_167541621.1 VapA/VapB family virulence-associated protein -
XDD1_RS03820 793487..795109 + 1623 WP_045968842.1 peptide ABC transporter substrate-binding protein -
XDD1_RS03825 795149..795553 - 405 WP_045968844.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
XDD1_RS03830 795606..795788 - 183 WP_045968846.1 type II toxin-antitoxin system HicA family toxin Toxin
XDD1_RS03835 795881..799561 - 3681 WP_045968848.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7061.38 Da        Isoelectric Point: 11.5111

>T284894 WP_045968846.1 NZ_FO704550:c795788-795606 [Xenorhabdus doucetiae]
MNSSDLMRLLEKNGWKLKRIKGSHHQFTHLEFSVVITVPHPRRDIKRGTLNKILKDAKIK

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15093.09 Da        Isoelectric Point: 4.9289

>AT284894 WP_045968844.1 NZ_FO704550:c795553-795149 [Xenorhabdus doucetiae]
MLYPAFVEIDQDGSASGWFPDVAGCIFAGNTLEEAHSDAQSAINAHFELMKEQNLEFPFPKSMQEHLAEKAAEYQNGQWL
LIPVNMSQFEDKTERINITLPLRLINRIDAKVKQHPEYGSRSGFLALAARKALQ

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A068QNK7

References