Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 544945..545594 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name vapC Uniprot ID A0A068QR47
Locus tag XDD1_RS02710 Protein ID WP_045968453.1
Coordinates 544945..545334 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A068QNX2
Locus tag XDD1_RS02715 Protein ID WP_045968455.1
Coordinates 545334..545594 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XDD1_RS02700 540448..543750 + 3303 WP_071827238.1 hypothetical protein -
XDD1_RS02705 543737..544882 + 1146 WP_045968450.1 hypothetical protein -
XDD1_RS02710 544945..545334 - 390 WP_045968453.1 type II toxin-antitoxin system VapC family toxin Toxin
XDD1_RS02715 545334..545594 - 261 WP_045968455.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
XDD1_RS02720 545873..548050 + 2178 WP_045968457.1 indolepyruvate ferredoxin oxidoreductase subunit alpha -
XDD1_RS02725 548066..549622 + 1557 WP_045968459.1 indolepyruvate oxidoreductase subunit beta family protein -
XDD1_RS02730 549639..550058 + 420 WP_045968461.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14391.41 Da        Isoelectric Point: 6.2212

>T284892 WP_045968453.1 NZ_FO704550:c545334-544945 [Xenorhabdus doucetiae]
MYMLDTNIVSYIFRQHPTVIAKLRTVSPSEIGISSITEAELRYGLARRQNSTLEHIVNTFIDSITVYDWDQNAAKVYGTL
RAGMEKTGRTMGTMDQLIAAHALSRGLTLVTSDSAFGMVSDLTIEDWTK

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10100.29 Da        Isoelectric Point: 5.0745

>AT284892 WP_045968455.1 NZ_FO704550:c545594-545334 [Xenorhabdus doucetiae]
MERVAKIFKNGRNQAVRLPVAFEFDTDHVYIRKNENGDVILSKNKSTDNWDSFLNMLHTLSVPDDFLNINERNQEITQRD
PFGDIF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068QR47

Antitoxin

Source ID Structure
AlphaFold DB A0A068QNX2

References