Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 544945..545594 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name vapC Uniprot ID A0A068QR47
Locus tag XDD1_RS02710 Protein ID WP_045968453.1
Coordinates 544945..545334 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A068QNX2
Locus tag XDD1_RS02715 Protein ID WP_045968455.1
Coordinates 545334..545594 (-) Length 87 a.a.

Genomic Context

XDD1_RS02700XDD1_RS02705XDD1_RS02720XDD1_RS02725XDD1_RS02730XDD1_RS02710XDD1_RS02715
Location: 540448..543750 (3303 bp)
Type: Others
Protein ID: WP_071827238.1
Location: 543737..544882 (1146 bp)
Type: Others
Protein ID: WP_045968450.1
Location: 545873..548050 (2178 bp)
Type: Others
Protein ID: WP_045968457.1
Location: 548066..549622 (1557 bp)
Type: Others
Protein ID: WP_045968459.1
Location: 549639..550058 (420 bp)
Type: Others
Protein ID: WP_045968461.1
Location: 544945..545334 (390 bp)
Type: Toxin
Protein ID: WP_045968453.1
Location: 545334..545594 (261 bp)
Type: Antitoxin
Protein ID: WP_045968455.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XDD1_RS02700540448..543750+3303WP_071827238.1hypothetical protein-
XDD1_RS02705543737..544882+1146WP_045968450.1hypothetical protein-
XDD1_RS02710544945..545334-390WP_045968453.1type II toxin-antitoxin system VapC family toxinToxin
XDD1_RS02715545334..545594-261WP_045968455.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
XDD1_RS02720545873..548050+2178WP_045968457.1indolepyruvate ferredoxin oxidoreductase subunit alpha-
XDD1_RS02725548066..549622+1557WP_045968459.1indolepyruvate oxidoreductase subunit beta family protein-
XDD1_RS02730549639..550058+420WP_045968461.1acyl-CoA thioesterase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14391.41 Da        Isoelectric Point: 6.2212

>T284892 WP_045968453.1 NZ_FO704550:c545334-544945 [Xenorhabdus doucetiae]
MYMLDTNIVSYIFRQHPTVIAKLRTVSPSEIGISSITEAELRYGLARRQNSTLEHIVNTFIDSITVYDWDQNAAKVYGTL
RAGMEKTGRTMGTMDQLIAAHALSRGLTLVTSDSAFGMVSDLTIEDWTK

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10100.29 Da        Isoelectric Point: 5.0745

>AT284892 WP_045968455.1 NZ_FO704550:c545594-545334 [Xenorhabdus doucetiae]
MERVAKIFKNGRNQAVRLPVAFEFDTDHVYIRKNENGDVILSKNKSTDNWDSFLNMLHTLSVPDDFLNINERNQEITQRD
PFGDIF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A068QR47

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A068QNX2

References