Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 20904..21735 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name itaT Uniprot ID A0A068QMN7
Locus tag XDD1_RS00145 Protein ID WP_045967677.1
Coordinates 20904..21449 (-) Length 182 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A0A068QLX4
Locus tag XDD1_RS00150 Protein ID WP_045967679.1
Coordinates 21430..21735 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XDD1_RS00130 18282..18875 + 594 WP_197540997.1 rhomboid family intramembrane serine protease -
XDD1_RS00135 18889..20337 - 1449 WP_045967672.1 NAD(P)/FAD-dependent oxidoreductase -
XDD1_RS00140 20524..20850 - 327 WP_045967675.1 DUF305 domain-containing protein -
XDD1_RS00145 20904..21449 - 546 WP_045967677.1 GNAT family N-acetyltransferase Toxin
XDD1_RS00150 21430..21735 - 306 WP_045967679.1 DUF1778 domain-containing protein Antitoxin
XDD1_RS00155 22061..24085 - 2025 WP_045973257.1 protease Lon-related BREX system protein BrxL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-160)

Antitoxin

Vibrio phage ICP1, Orf50

(17-94)


Sequences

Toxin        


Download         Length: 182 a.a.        Molecular weight: 19802.08 Da        Isoelectric Point: 7.7415

>T284888 WP_045967677.1 NZ_FO704550:c21449-20904 [Xenorhabdus doucetiae]
MEKSLNEIRVEYICVNYQSDITYLGQKAFDCGNHVINRYVRSSLKSNVANGNCVAKALIDAETGELLGVCSFTGYSLAKS
RLSGVLSGSMPSDLSVIRLVMLGVSVKHQKKGYGHILMREFLEHAIKVHQVMPIKGIFLDADPDAVAFYILLGFVELGTP
ASNGTTPMFLKIQDLLAAIPY

Download         Length: 546 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11332.09 Da        Isoelectric Point: 10.5421

>AT284888 WP_045967679.1 NZ_FO704550:c21735-21430 [Xenorhabdus doucetiae]
MATISVKKPQKEAKNARVELKTSTELKETLRQAAQVAGVDLSAFILSAAFERAEEVLENQKRRELDEENWRTLNVLIAEP
ASPTLALRALMRKNKNGKVTK

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068QMN7

Antitoxin

Source ID Structure
AlphaFold DB A0A068QLX4

References