Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 20904..21735 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name itaT Uniprot ID A0A068QMN7
Locus tag XDD1_RS00145 Protein ID WP_045967677.1
Coordinates 20904..21449 (-) Length 182 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A0A068QLX4
Locus tag XDD1_RS00150 Protein ID WP_045967679.1
Coordinates 21430..21735 (-) Length 102 a.a.

Genomic Context

XDD1_RS00130XDD1_RS00135XDD1_RS00140XDD1_RS00145XDD1_RS00150XDD1_RS00155
Location: 18282..18875 (594 bp)
Type: Others
Protein ID: WP_197540997.1
Location: 18889..20337 (1449 bp)
Type: Others
Protein ID: WP_045967672.1
Location: 20524..20850 (327 bp)
Type: Others
Protein ID: WP_045967675.1
Location: 20904..21449 (546 bp)
Type: Toxin
Protein ID: WP_045967677.1
Location: 21430..21735 (306 bp)
Type: Antitoxin
Protein ID: WP_045967679.1
Location: 22061..24085 (2025 bp)
Type: Others
Protein ID: WP_045973257.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XDD1_RS0013018282..18875+594WP_197540997.1rhomboid family intramembrane serine protease-
XDD1_RS0013518889..20337-1449WP_045967672.1NAD(P)/FAD-dependent oxidoreductase-
XDD1_RS0014020524..20850-327WP_045967675.1DUF305 domain-containing protein-
XDD1_RS0014520904..21449-546WP_045967677.1GNAT family N-acetyltransferaseToxin
XDD1_RS0015021430..21735-306WP_045967679.1DUF1778 domain-containing proteinAntitoxin
XDD1_RS0015522061..24085-2025WP_045973257.1protease Lon-related BREX system protein BrxL-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-160)

Antitoxin

Vibrio phage ICP1, Orf50

(17-94)


Sequences

Toxin        


Download         Length: 182 a.a.        Molecular weight: 19802.08 Da        Isoelectric Point: 7.7415

>T284888 WP_045967677.1 NZ_FO704550:c21449-20904 [Xenorhabdus doucetiae]
MEKSLNEIRVEYICVNYQSDITYLGQKAFDCGNHVINRYVRSSLKSNVANGNCVAKALIDAETGELLGVCSFTGYSLAKS
RLSGVLSGSMPSDLSVIRLVMLGVSVKHQKKGYGHILMREFLEHAIKVHQVMPIKGIFLDADPDAVAFYILLGFVELGTP
ASNGTTPMFLKIQDLLAAIPY

Download         Length: 546 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11332.09 Da        Isoelectric Point: 10.5421

>AT284888 WP_045967679.1 NZ_FO704550:c21735-21430 [Xenorhabdus doucetiae]
MATISVKKPQKEAKNARVELKTSTELKETLRQAAQVAGVDLSAFILSAAFERAEEVLENQKRRELDEENWRTLNVLIAEP
ASPTLALRALMRKNKNGKVTK

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A068QMN7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A068QLX4

References