Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 200559..201195 Replicon chromosome
Accession NZ_CP128552
Organism Priestia aryabhattai strain XT37

Toxin (Protein)


Gene name mazF Uniprot ID D5DWT4
Locus tag QUH71_RS01130 Protein ID WP_013055004.1
Coordinates 200845..201195 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5DWT3
Locus tag QUH71_RS01125 Protein ID WP_013055003.1
Coordinates 200559..200840 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUH71_RS01100 (QUH71_01100) 195925..196896 + 972 WP_033580801.1 UV DNA damage repair endonuclease UvsE -
QUH71_RS01105 (QUH71_01105) 196905..197507 - 603 WP_028411882.1 rhomboid family intramembrane serine protease -
QUH71_RS01110 (QUH71_01110) 197572..197937 + 366 WP_289578955.1 holo-ACP synthase -
QUH71_RS01115 (QUH71_01115) 197996..199054 + 1059 WP_033580802.1 outer membrane lipoprotein carrier protein LolA -
QUH71_RS01120 (QUH71_01120) 199168..200358 + 1191 WP_289578648.1 alanine racemase -
QUH71_RS01125 (QUH71_01125) 200559..200840 + 282 WP_013055003.1 hypothetical protein Antitoxin
QUH71_RS01130 (QUH71_01130) 200845..201195 + 351 WP_013055004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QUH71_RS01135 (QUH71_01135) 201353..202189 + 837 WP_013055005.1 RsbT co-antagonist protein RsbRA -
QUH71_RS01140 (QUH71_01140) 202192..202548 + 357 WP_013055006.1 STAS domain-containing protein -
QUH71_RS01145 (QUH71_01145) 202552..202953 + 402 WP_013055007.1 anti-sigma regulatory factor -
QUH71_RS01150 (QUH71_01150) 202967..203977 + 1011 WP_013055008.1 PP2C family protein-serine/threonine phosphatase -
QUH71_RS01155 (QUH71_01155) 204037..204369 + 333 WP_013055009.1 anti-sigma factor antagonist -
QUH71_RS01160 (QUH71_01160) 204366..204851 + 486 WP_025753516.1 anti-sigma B factor RsbW -
QUH71_RS01165 (QUH71_01165) 204817..205611 + 795 WP_013055011.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.96 Da        Isoelectric Point: 4.8781

>T284883 WP_013055004.1 NZ_CP128552:200845-201195 [Priestia aryabhattai]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10691.22 Da        Isoelectric Point: 8.5339

>AT284883 WP_013055003.1 NZ_CP128552:200559-200840 [Priestia aryabhattai]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6AMB9

References