Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 4042266..4043149 Replicon chromosome
Accession NZ_CP128550
Organism Pseudomonas alloputida strain NMI5594_09

Toxin (Protein)


Gene name - Uniprot ID Q88K57
Locus tag LU693_RS18735 Protein ID WP_003250527.1
Coordinates 4042266..4042703 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID I7C3Q7
Locus tag LU693_RS18740 Protein ID WP_003250525.1
Coordinates 4042700..4043149 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU693_RS18710 (LU693_018710) 4037810..4038199 - 390 WP_049587628.1 hypothetical protein -
LU693_RS18715 (LU693_018715) 4038202..4038450 - 249 Protein_3685 PAAR domain-containing protein -
LU693_RS18720 (LU693_018720) 4038614..4039843 - 1230 WP_049587623.1 acyl-CoA dehydrogenase -
LU693_RS18725 (LU693_018725) 4039984..4040910 + 927 WP_010953387.1 LysR family transcriptional regulator -
LU693_RS18730 (LU693_018730) 4041104..4042258 + 1155 WP_049587669.1 aminotransferase class V-fold PLP-dependent enzyme -
LU693_RS18735 (LU693_018735) 4042266..4042703 - 438 WP_003250527.1 RES family NAD+ phosphorylase Toxin
LU693_RS18740 (LU693_018740) 4042700..4043149 - 450 WP_003250525.1 DUF2384 domain-containing protein Antitoxin
LU693_RS18745 (LU693_018745) 4043292..4043945 - 654 WP_010953384.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
LU693_RS18750 (LU693_018750) 4044049..4044972 + 924 WP_010953383.1 LysR family transcriptional regulator -
LU693_RS18755 (LU693_018755) 4045021..4045851 + 831 WP_003250518.1 AraC family transcriptional regulator -
LU693_RS18760 (LU693_018760) 4045902..4046486 + 585 WP_010953382.1 LysE family transporter -
LU693_RS18765 (LU693_018765) 4046526..4047725 - 1200 WP_232894293.1 sugar transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15990.29 Da        Isoelectric Point: 5.6007

>T284874 WP_003250527.1 NZ_CP128550:c4042703-4042266 [Pseudomonas alloputida]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDCSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 438 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16956.46 Da        Isoelectric Point: 5.7258

>AT284874 WP_003250525.1 NZ_CP128550:c4043149-4042700 [Pseudomonas alloputida]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6GW6

Antitoxin

Source ID Structure
AlphaFold DB I7C3Q7

References