284873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2031687..2032726 Replicon chromosome
Accession NZ_CP128550
Organism Pseudomonas alloputida strain NMI5594_09

Toxin (Protein)


Gene name PP_4152 Uniprot ID Q88FE5
Locus tag LU693_RS09275 Protein ID WP_010954922.1
Coordinates 2031687..2032262 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A2V4F8J0
Locus tag LU693_RS09280 Protein ID WP_049588231.1
Coordinates 2032259..2032726 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU693_RS09265 (LU693_009265) 2027316..2028539 + 1224 WP_010954925.1 NAD(P)/FAD-dependent oxidoreductase -
LU693_RS09270 (LU693_009270) 2028543..2031473 - 2931 WP_049588229.1 aminotransferase -
LU693_RS09275 (LU693_009275) 2031687..2032262 - 576 WP_010954922.1 PIN domain-containing protein Toxin
LU693_RS09280 (LU693_009280) 2032259..2032726 - 468 WP_049588231.1 helix-turn-helix domain-containing protein Antitoxin
LU693_RS09285 (LU693_009285) 2032874..2034478 - 1605 WP_010954920.1 ABC transporter ATP-binding protein -
LU693_RS09290 (LU693_009290) 2034480..2035499 - 1020 WP_010954919.1 ABC transporter permease -
LU693_RS09295 (LU693_009295) 2035501..2036574 - 1074 WP_010954918.1 microcin C ABC transporter permease YejB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21646.86 Da        Isoelectric Point: 5.5710

>T284873 WP_010954922.1 NZ_CP128550:c2032262-2031687 [Pseudomonas alloputida]
MKHSPFTAIYDANVLYPAPLRDFLMNLALTGIYRARWSASIHDEWKRNLLLNRPDLTPEHLDRTSSLMDAAVPDALVTDY
DSLVEGLDLPDRDDRHVLAAAIKCNASVIVTFNLKDFSKAVLGAFDIEPLHPDDFIADLWDLDKAAVLEAAQRQRISLKN
PPHSVQQYLDRLLQQKLPETVKLLSAFKFLL

Download         Length: 576 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17112.54 Da        Isoelectric Point: 6.3403

>AT284873 WP_049588231.1 NZ_CP128550:c2032726-2032259 [Pseudomonas alloputida]
MTTANLSSHVLPDEKEIAVAVESSRTLAAFLSTKSDTQRIELLNEENQRQVVEVPTFALRLFGEILSELALGNSVKVVPI
HAELTTQEAADLLNVSRPHLVKLLDEAVIPHTKTGRHRRVKFSDLVAYKDKRDGVSRAAIDALAAQAQELKMGYE

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q88FE5

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4F8J0

References