Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 290308..291299 Replicon chromosome
Accession NZ_CP128550
Organism Pseudomonas alloputida strain NMI5594_09

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LU693_RS01240 Protein ID WP_020190010.1
Coordinates 290308..290784 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q88R60
Locus tag LU693_RS01245 Protein ID WP_004575922.1
Coordinates 290826..291299 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU693_RS01220 (LU693_001220) 285451..286818 - 1368 WP_010951639.1 ATP-binding protein -
LU693_RS01225 (LU693_001225) 286820..287539 - 720 WP_010951640.1 response regulator -
LU693_RS01230 (LU693_001230) 287680..289977 + 2298 WP_010951641.1 TonB-dependent siderophore receptor -
LU693_RS01235 (LU693_001235) 290043..290249 - 207 WP_014860378.1 DUF3079 domain-containing protein -
LU693_RS01240 (LU693_001240) 290308..290784 + 477 WP_020190010.1 type II toxin-antitoxin system HigB family toxin Toxin
LU693_RS01245 (LU693_001245) 290826..291299 + 474 WP_004575922.1 transcriptional regulator Antitoxin
LU693_RS01250 (LU693_001250) 291304..291491 - 188 Protein_239 integrase -
LU693_RS01255 (LU693_001255) 291719..291934 + 216 WP_010951644.1 type II toxin-antitoxin system RelE/ParE family toxin -
LU693_RS01260 (LU693_001260) 291931..292254 - 324 WP_010951645.1 helix-turn-helix transcriptional regulator -
LU693_RS01265 (LU693_001265) 292821..295289 - 2469 WP_161989609.1 hypothetical protein -
LU693_RS01270 (LU693_001270) 295464..295739 - 276 WP_080516504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(114-152)

Antitoxin

Antitoxin HigA

(43-154)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18386.38 Da        Isoelectric Point: 10.3522

>T284870 WP_020190010.1 NZ_CP128550:290308-290784 [Pseudomonas alloputida]
MTGINPLAIARSPYIAHPDIWLTDIWIGDIFHPMLVRRDNTMRVITKAAVTKAIEVHGQWKAPLSLWLTTFDRATLRFES
FEQLRQTWATVSGWNVDRIPHSKLRPASRKGPLDIYVFDIKKNECRLIAWLNARTGTLYIKAILSHAEYDKWCRSDIR

Download         Length: 477 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17229.67 Da        Isoelectric Point: 4.4982

>AT284870 WP_004575922.1 NZ_CP128550:290826-291299 [Pseudomonas alloputida]
MKRDKIEANGLDAFIANISPMLDGLNTQMATMAQLLAACHDPIKDDAELEARMALIDELYSHADSEGHAAARFAEMVADR
VYEYESESVLVPFASQAEALAFLLSDRGVKQKDLSAIATQSAVSEILNNKRKMTVAQIKGFAEFFSVPVEFFMHGVV

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0CBJ4

References