Detailed information of TA system TA028487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 241448..242567
• Replicon: chromosome
• Accession: NC_019675
• Organism: Cyanobium gracile PCC 6307

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CYAGR_RS01140
• Protein ID: WP_051016990.1
• Coordinates: 241908..242567 (+)
• Length: 220 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: K9P2Z4
• Locus tag: CYAGR_RS01135
• Protein ID: WP_015107904.1
• Coordinates: 241448..241822 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYAGR_RS01120	238118..239803	+	1686	WP_015107901.1	DUF262 domain-containing protein	-
CYAGR_RS17535	239863..240552	+	690	WP_015107902.1	TerB family tellurite resistance protein	-
CYAGR_RS01130	240596..240943	+	348	WP_015107903.1	hypothetical protein	-
CYAGR_RS17995	240952..241209	+	258	WP_156818336.1	hypothetical protein	-
CYAGR_RS01135	241448..241822	+	375	WP_015107904.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
CYAGR_RS01140	241908..242567	+	660	WP_051016990.1	RES family NAD+ phosphorylase	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (40-161)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (14-70)

Sequences

Toxin

Protein

• Length: 220 a.a.
• Molecular weight: 24055.29 Da
• Isoelectric Point: 6.3382

>T28487 WP_051016990.1 NC_019675:241908-242567 [Cyanobium gracile PCC 6307]
VDGLLEQARLEQLIDTVKPPIPCDWADASEGRPMPSHPLLLTPFRYPPLISGSRFGRPHQRHLFYGARSLETALAERSFH
ALRMLEDSPLPEGARLQRLQTAFSVEITAKRGLSLQTHLTPEALSAITDPSSYAASQRCGDAMRERGVQAFEVPSARSPQ
TPPVVGVLTPYAFSSTPFDFQDWTLEISAEGVTAVSFAGGLKGTFAREQFLVDGRWPVP

Nucleotide

• Length: 660 bp

>T28487 NC_019675:241908-242567 [Cyanobium gracile PCC 6307]
GTGGATGGGCTCCTGGAACAGGCACGCCTGGAGCAGCTGATCGACACGGTGAAGCCGCCGATTCCCTGCGACTGGGCTGA
TGCTTCCGAAGGCCGGCCGATGCCGTCGCACCCGCTGTTGCTGACTCCCTTTCGCTATCCGCCCCTGATCAGTGGCTCTC
GCTTTGGGCGCCCGCACCAGCGCCATCTCTTCTACGGGGCGCGATCGCTGGAGACGGCTCTGGCCGAGCGCTCCTTCCAC
GCCCTGCGGATGCTGGAAGACTCGCCGCTGCCCGAAGGTGCCCGCCTTCAGCGCCTGCAGACCGCCTTCTCGGTAGAGAT
CACAGCGAAACGCGGCCTGTCGTTGCAGACCCACCTCACACCCGAGGCCCTGTCTGCCATCACGGATCCCAGCAGCTACG
CAGCCAGTCAGCGCTGCGGCGATGCCATGCGGGAGCGCGGCGTTCAGGCCTTCGAAGTGCCGTCGGCCCGCTCCCCCCAG
ACGCCTCCTGTGGTTGGGGTCCTCACCCCCTATGCCTTCAGCAGCACGCCGTTCGATTTCCAGGACTGGACTCTGGAGAT
CAGCGCCGAAGGGGTGACGGCTGTGTCCTTTGCAGGGGGGCTCAAGGGAACCTTCGCCAGGGAGCAGTTTCTGGTGGACG
GGCGCTGGCCCGTGCCGTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13646.74 Da
• Isoelectric Point: 8.0901

>AT28487 WP_015107904.1 NC_019675:241448-241822 [Cyanobium gracile PCC 6307]
MPPALAPLPQEPLTKSDAQLVAEACNRAAQALGLTRDELSAVVGKHRTSIERTGLDPSTKEGELALLFVRVYRSLHALMG
GDQALMRHWMEQPNLHFGQQPPRQLLARVEGLTRVVSYLDALRG

Nucleotide

• Length: 375 bp

>AT28487 NC_019675:241448-241822 [Cyanobium gracile PCC 6307]
ATGCCTCCTGCCCTAGCTCCGCTCCCCCAGGAGCCGCTCACCAAGTCCGATGCCCAGTTGGTGGCCGAGGCCTGCAATCG
TGCGGCCCAGGCTCTGGGCCTCACGCGCGACGAGCTGAGCGCCGTGGTGGGCAAGCACCGCACCAGCATCGAACGCACGG
GCTTGGATCCCAGTACCAAAGAAGGCGAGCTGGCGCTGCTGTTCGTGCGGGTCTATCGCAGCCTGCATGCCCTCATGGGT
GGCGATCAGGCCCTGATGCGCCACTGGATGGAGCAGCCCAACCTCCACTTCGGCCAACAGCCGCCGCGTCAGTTGCTGGC
GCGCGTGGAAGGCCTCACCCGCGTTGTCAGCTACCTCGATGCCCTCCGCGGCTGA

Structures

Antitoxin

• AlphaFold DB: K9P2Z4