Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4856494..4857102 Replicon chromosome
Accession NZ_CP128548
Organism Pseudomonas kurunegalensis strain NMI3456_12

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LU664_RS23080 Protein ID WP_164525070.1
Coordinates 4856812..4857102 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A6G6V4Q8
Locus tag LU664_RS23075 Protein ID WP_060499944.1
Coordinates 4856494..4856802 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU664_RS23050 (LU664_023050) 4851664..4853526 - 1863 WP_060501849.1 protein translocase subunit SecD -
LU664_RS23055 (LU664_023055) 4853590..4853925 - 336 WP_008092587.1 preprotein translocase subunit YajC -
LU664_RS23060 (LU664_023060) 4853968..4855083 - 1116 WP_014589748.1 tRNA guanosine(34) transglycosylase Tgt -
LU664_RS23065 (LU664_023065) 4855098..4856147 - 1050 WP_104834019.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
LU664_RS23075 (LU664_023075) 4856494..4856802 - 309 WP_060499944.1 putative addiction module antidote protein Antitoxin
LU664_RS23080 (LU664_023080) 4856812..4857102 - 291 WP_164525070.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LU664_RS23085 (LU664_023085) 4857214..4859694 - 2481 WP_225521444.1 TonB-dependent receptor -
LU664_RS23090 (LU664_023090) 4859812..4860753 - 942 WP_164525071.1 FecR domain-containing protein -
LU664_RS23095 (LU664_023095) 4860753..4861265 - 513 WP_164525274.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10711.19 Da        Isoelectric Point: 8.9632

>T284865 WP_164525070.1 NZ_CP128548:c4857102-4856812 [Pseudomonas kurunegalensis]
VKTILTTDDFDAWFSKLSDKRSAMRIQARIDRAEAGNFGDCQAVGEGVSEMRIHYGPGYRVYFTQRGLEIVILLAGGDKS
TQSKDIKTALDIARRL

Download         Length: 291 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10817.32 Da        Isoelectric Point: 6.2202

>AT284865 WP_060499944.1 NZ_CP128548:c4856802-4856494 [Pseudomonas kurunegalensis]
MGNVKLKKWDSAEHLKTDEDMALYLEACIEEAGDDAAFIAKALGTIARAKGMAQLARDTGLGRESLYKALSGEGNPSFAT
ILKVTRALGLQLHADVASTHTG

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6V4Q8

References