Detailed information of TA system TA028486

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 228596..229161
• Replicon: chromosome
• Accession: NC_019675
• Organism: Cyanobium gracile PCC 6307

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K9P392
• Locus tag: CYAGR_RS01095
• Protein ID: WP_015107897.1
• Coordinates: 228596..228970 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CYAGR_RS01100
• Protein ID: WP_015107898.1
• Coordinates: 228967..229161 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYAGR_RS01080	223861..225081	-	1221	WP_015107894.1	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C-terminal domain	-
CYAGR_RS01085	225220..226230	+	1011	WP_015107895.1	LCP family protein	-
CYAGR_RS01090	226293..228458	-	2166	WP_015107896.1	AAA family ATPase	-
CYAGR_RS01095	228596..228970	-	375	WP_015107897.1	type II toxin-antitoxin system VapC family toxin	Toxin
CYAGR_RS01100	228967..229161	-	195	WP_015107898.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CYAGR_RS01105	229287..230189	+	903	WP_015107899.1	hypothetical protein	-
CYAGR_RS01110	230260..233166	+	2907	WP_015107900.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13650.84 Da
• Isoelectric Point: 6.0750

>T28486 WP_015107897.1 NC_019675:c228970-228596 [Cyanobium gracile PCC 6307]
VILVDTSVWVDHLRCGLPRLATRLQDGEVLIHPWVIGEIACGNLRDRGQVLSLLQGLPAAVVASDEEVLLLIERDQLMGR
GIGYVDVHLIASARLSRCHLWTQDRRLAAVAKEQRLVVAEAESG

Nucleotide

• Length: 375 bp

>T28486 NC_019675:c228970-228596 [Cyanobium gracile PCC 6307]
GTGATCCTCGTCGACACCTCCGTGTGGGTGGATCACCTGCGCTGTGGTTTGCCGCGCCTCGCTACGCGCCTCCAGGACGG
TGAGGTGCTGATCCATCCCTGGGTGATCGGCGAAATCGCCTGCGGGAATCTGCGCGATCGCGGGCAGGTGCTGAGCCTTC
TGCAGGGTCTGCCGGCAGCCGTGGTGGCCAGCGACGAGGAAGTGCTGCTGCTGATCGAGCGCGACCAGCTGATGGGCCGA
GGGATCGGTTATGTGGATGTTCACCTGATCGCCTCCGCCCGATTGAGCCGCTGCCACCTGTGGACCCAGGATCGTCGCCT
CGCCGCCGTGGCTAAGGAGCAAAGGTTGGTGGTGGCGGAGGCAGAGTCCGGGTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7031.08 Da
• Isoelectric Point: 7.9972

>AT28486 WP_015107898.1 NC_019675:c229161-228967 [Cyanobium gracile PCC 6307]
MRTTVTLDDDLLARAEQLCGDLERSALLKEALRALVQRESAKRLAALGGSEPALEPIPRRRSTT

Nucleotide

• Length: 195 bp

>AT28486 NC_019675:c229161-228967 [Cyanobium gracile PCC 6307]
ATGCGAACCACCGTGACGCTCGACGACGACCTGCTCGCCAGGGCCGAGCAGCTGTGCGGCGATCTGGAACGCAGCGCCCT
GCTCAAGGAAGCCCTTCGGGCCCTCGTGCAACGCGAAAGCGCCAAGCGTCTCGCAGCGCTGGGAGGCAGTGAACCCGCGC
TGGAGCCGATCCCCCGTCGCCGCAGCACGACGTGA

Structures

Toxin

• AlphaFold DB: K9P392