Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 819304..819944 Replicon chromosome
Accession NZ_CP128544
Organism Pseudomonas mosselii strain NMI4849_14

Toxin (Protein)


Gene name vapC Uniprot ID A0A1H9S264
Locus tag LU678_RS03905 Protein ID WP_028691288.1
Coordinates 819304..819714 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A246GUY5
Locus tag LU678_RS03910 Protein ID WP_036986184.1
Coordinates 819714..819944 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU678_RS03880 (LU678_003880) 816302..816727 - 426 WP_028691293.1 DUF2946 domain-containing protein -
LU678_RS03885 (LU678_003885) 816753..817235 - 483 WP_028691292.1 copper chaperone PCu(A)C -
LU678_RS03890 (LU678_003890) 817283..817672 - 390 WP_028691291.1 DUF2946 domain-containing protein -
LU678_RS03895 (LU678_003895) 817913..818767 - 855 WP_028691290.1 SPFH domain-containing protein -
LU678_RS03900 (LU678_003900) 818794..819231 - 438 WP_028691289.1 NfeD family protein -
LU678_RS03905 (LU678_003905) 819304..819714 - 411 WP_028691288.1 tRNA(fMet)-specific endonuclease VapC Toxin
LU678_RS03910 (LU678_003910) 819714..819944 - 231 WP_036986184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LU678_RS03915 (LU678_003915) 820027..820755 - 729 WP_028691287.1 cobalt-precorrin-6A reductase -
LU678_RS03920 (LU678_003920) 820752..821846 - 1095 WP_028691286.1 cobalt-precorrin-5B (C(1))-methyltransferase -
LU678_RS03925 (LU678_003925) 821839..823050 - 1212 WP_028691285.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
LU678_RS03930 (LU678_003930) 823218..824543 + 1326 WP_028691284.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15234.59 Da        Isoelectric Point: 9.5447

>T284851 WP_028691288.1 NZ_CP128544:c819714-819304 [Pseudomonas mosselii]
MLRYMLDTNICIFTIKNKPQVVREAFNRHHGQLAISTVTLMELIYGAEKSAAPERNLAIVEGFAARLDVLDYDIQGAAHT
AQLRAELAKAGTPIGPYDRMIAGHARARGLTLVTNNLREFQRVPGLRVEDWVTHPR

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8459.36 Da        Isoelectric Point: 4.2821

>AT284851 WP_036986184.1 NZ_CP128544:c819944-819714 [Pseudomonas mosselii]
MEQGAVFKSNRSQAIRMPKALALPEDVTRVDIVAVGRSRIISPAGESWDSWFEGDDVSSDFMASREQPADQEREGF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H9S264

Antitoxin

Source ID Structure
AlphaFold DB A0A246GUY5

References