Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 7819010..7819680 Replicon chromosome
Accession NC_019673
Organism Saccharothrix espanaensis DSM 44229

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BN6_RS34050 Protein ID WP_015104404.1
Coordinates 7819010..7819408 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BN6_RS34055 Protein ID WP_041315077.1
Coordinates 7819405..7819680 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN6_RS34030 7814177..7815109 + 933 WP_148303130.1 pentapeptide repeat-containing protein -
BN6_RS34035 7815737..7817299 - 1563 WP_148303475.1 cobyric acid synthase -
BN6_RS34040 7817310..7818017 + 708 WP_041315073.1 hypothetical protein -
BN6_RS34045 7818096..7818953 - 858 WP_015104403.1 type I methionyl aminopeptidase -
BN6_RS34050 7819010..7819408 - 399 WP_015104404.1 type II toxin-antitoxin system VapC family toxin Toxin
BN6_RS34055 7819405..7819680 - 276 WP_041315077.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BN6_RS34060 7819790..7821583 - 1794 WP_041319026.1 penicillin-binding protein -
BN6_RS34065 7821607..7822461 - 855 WP_015104407.1 GNAT family N-acetyltransferase -
BN6_RS34070 7822677..7823840 - 1164 WP_015104408.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14256.50 Da        Isoelectric Point: 4.7492

>T28485 WP_015104404.1 NC_019673:c7819408-7819010 [Saccharothrix espanaensis DSM 44229]
VIYFDTSALVKLVRTEAETPDLRAWIEDRSGRRAVSSSLARVELIRAVRVEGDEAIRVATRVLVEIDQLPMTMDLLDAAG
ALPLLLKSLDAIHLASALRLRGDLDAFVAYDKKLLVAADEMGLPTASPGTSG

Download         Length: 399 bp

>T28485 NC_019673:c7819408-7819010 [Saccharothrix espanaensis DSM 44229]
GTGATCTACTTCGACACCTCGGCCCTGGTGAAGCTCGTCCGGACCGAGGCCGAGACGCCGGACCTGCGCGCGTGGATCGA
AGACCGGTCGGGGCGGCGGGCCGTCAGCAGCTCACTGGCCAGGGTGGAGTTGATCCGGGCGGTGCGCGTCGAGGGCGACG
AGGCGATCCGGGTGGCGACCCGCGTCCTCGTCGAGATCGACCAGCTGCCGATGACCATGGACCTGCTGGACGCCGCCGGG
GCGCTCCCGCTCCTGCTCAAGTCGCTGGACGCCATCCACCTCGCGTCCGCGCTGCGGCTGCGCGGTGACCTGGACGCGTT
CGTCGCCTACGACAAGAAGCTGCTCGTCGCCGCCGACGAGATGGGGCTGCCGACCGCGTCGCCCGGCACGTCGGGCTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10221.48 Da        Isoelectric Point: 5.1817

>AT28485 WP_041315077.1 NC_019673:c7819680-7819405 [Saccharothrix espanaensis DSM 44229]
MEQIGLRELRHHTGEYLRRAEAGERIAVTDHGRVVAEIGPPTEDASSLRDQLIVNGELLRGRGGPFPEPLPPTTGTPLSE
VLRQMREDERW

Download         Length: 276 bp

>AT28485 NC_019673:c7819680-7819405 [Saccharothrix espanaensis DSM 44229]
ATGGAGCAGATCGGCCTTCGTGAGTTGCGCCACCACACGGGCGAGTACCTGCGTCGGGCCGAGGCCGGCGAGCGGATCGC
GGTCACCGACCACGGTCGGGTGGTCGCGGAGATCGGGCCGCCGACCGAGGACGCGTCGAGCCTGCGCGACCAGCTGATCG
TCAACGGCGAACTCCTGCGCGGCCGAGGCGGGCCGTTCCCGGAACCGCTGCCGCCCACGACCGGCACCCCGCTGTCCGAG
GTGCTGCGGCAGATGCGGGAGGACGAGCGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References