Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4017687..4018726 Replicon chromosome
Accession NZ_CP128542
Organism Pseudomonas asiatica strain NMI3658_15

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A2N5BP56
Locus tag LU687_RS19170 Protein ID WP_015271072.1
Coordinates 4018151..4018726 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A2N5BP88
Locus tag LU687_RS19165 Protein ID WP_015271071.1
Coordinates 4017687..4018154 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU687_RS19145 (LU687_019145) 4013751..4014770 + 1020 WP_013973404.1 ABC transporter permease -
LU687_RS19150 (LU687_019150) 4014772..4016385 + 1614 WP_015271068.1 ABC transporter ATP-binding protein -
LU687_RS19155 (LU687_019155) 4016843..4017085 + 243 WP_015271069.1 hypothetical protein -
LU687_RS19160 (LU687_019160) 4017242..4017505 + 264 WP_015271070.1 DUF3077 domain-containing protein -
LU687_RS19165 (LU687_019165) 4017687..4018154 + 468 WP_015271071.1 helix-turn-helix domain-containing protein Antitoxin
LU687_RS19170 (LU687_019170) 4018151..4018726 + 576 WP_015271072.1 PIN domain-containing protein Toxin
LU687_RS19175 (LU687_019175) 4018941..4021871 + 2931 WP_015271073.1 aminotransferase -
LU687_RS19180 (LU687_019180) 4022234..4023139 + 906 WP_013973410.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3996616..4021871 25255


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

SinI-like, DNA-binding domain

(84-129)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21970.23 Da        Isoelectric Point: 5.0798

>T284845 WP_015271072.1 NZ_CP128542:4018151-4018726 [Pseudomonas asiatica]
MKHSPFTAIYDANVLYPAPLRDFLMNLALTGIYRARWSTKIHDEWKRNLLLNRPDLTLEQVDRTSRRMDAAVPDALVTDY
ESLVEGLDLPDKDDRHVLAAAIKCNASVIVTFNLKDFPETALDVFDIEPLHPDDFIADLWDLDKAAVLEAAQRQRMSLKN
PPHSVQQYLDRLLQQKLPESVKLLSEFKFLL

Download         Length: 576 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17366.86 Da        Isoelectric Point: 5.3408

>AT284845 WP_015271071.1 NZ_CP128542:4017687-4018154 [Pseudomonas asiatica]
MTTADLSRKMLPDEKEIAVAVESSRTLAAFLSTKSDTQRIELLNEENQRQVVEVPTFALRLFGEILSELALGNSVKVVPI
HAELTTQEAADLLNVSRPYLVKLLDESVIPHTKTGRHRRVKFSDLVAYKDKRDEVSRAAMDALAAEAQELRMGYE

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N5BP56

Antitoxin

Source ID Structure
AlphaFold DB A0A2N5BP88

References