Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4017687..4018726 Replicon chromosome
Accession NZ_CP128542
Organism Pseudomonas asiatica strain NMI3658_15

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A2N5BP56
Locus tag LU687_RS19170 Protein ID WP_015271072.1
Coordinates 4018151..4018726 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A2N5BP88
Locus tag LU687_RS19165 Protein ID WP_015271071.1
Coordinates 4017687..4018154 (+) Length 156 a.a.

Genomic Context

LU687_RS19145LU687_RS19150LU687_RS19155LU687_RS19160LU687_RS19165LU687_RS19170LU687_RS19175LU687_RS19180
Location: 4013751..4014770 (1020 bp)
Type: Others
Protein ID: WP_013973404.1
Location: 4014772..4016385 (1614 bp)
Type: Others
Protein ID: WP_015271068.1
Location: 4016843..4017085 (243 bp)
Type: Others
Protein ID: WP_015271069.1
Location: 4017242..4017505 (264 bp)
Type: Others
Protein ID: WP_015271070.1
Location: 4017687..4018154 (468 bp)
Type: Antitoxin
Protein ID: WP_015271071.1
Location: 4018151..4018726 (576 bp)
Type: Toxin
Protein ID: WP_015271072.1
Location: 4018941..4021871 (2931 bp)
Type: Others
Protein ID: WP_015271073.1
Location: 4022234..4023139 (906 bp)
Type: Others
Protein ID: WP_013973410.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LU687_RS19145 (LU687_019145)4013751..4014770+1020WP_013973404.1ABC transporter permease-
LU687_RS19150 (LU687_019150)4014772..4016385+1614WP_015271068.1ABC transporter ATP-binding protein-
LU687_RS19155 (LU687_019155)4016843..4017085+243WP_015271069.1hypothetical protein-
LU687_RS19160 (LU687_019160)4017242..4017505+264WP_015271070.1DUF3077 domain-containing protein-
LU687_RS19165 (LU687_019165)4017687..4018154+468WP_015271071.1helix-turn-helix domain-containing proteinAntitoxin
LU687_RS19170 (LU687_019170)4018151..4018726+576WP_015271072.1PIN domain-containing proteinToxin
LU687_RS19175 (LU687_019175)4018941..4021871+2931WP_015271073.1aminotransferase-
LU687_RS19180 (LU687_019180)4022234..4023139+906WP_013973410.1LysR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--3996616..402187125255


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

SinI-like, DNA-binding domain

(84-129)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21970.23 Da        Isoelectric Point: 5.0798

>T284845 WP_015271072.1 NZ_CP128542:4018151-4018726 [Pseudomonas asiatica]
MKHSPFTAIYDANVLYPAPLRDFLMNLALTGIYRARWSTKIHDEWKRNLLLNRPDLTLEQVDRTSRRMDAAVPDALVTDY
ESLVEGLDLPDKDDRHVLAAAIKCNASVIVTFNLKDFPETALDVFDIEPLHPDDFIADLWDLDKAAVLEAAQRQRMSLKN
PPHSVQQYLDRLLQQKLPESVKLLSEFKFLL

Download         Length: 576 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17366.86 Da        Isoelectric Point: 5.3408

>AT284845 WP_015271071.1 NZ_CP128542:4017687-4018154 [Pseudomonas asiatica]
MTTADLSRKMLPDEKEIAVAVESSRTLAAFLSTKSDTQRIELLNEENQRQVVEVPTFALRLFGEILSELALGNSVKVVPI
HAELTTQEAADLLNVSRPYLVKLLDESVIPHTKTGRHRRVKFSDLVAYKDKRDEVSRAAMDALAAEAQELRMGYE

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2N5BP56

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2N5BP88

References