Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 288388..289379 Replicon chromosome
Accession NZ_CP128540
Organism Pseudomonas alloputida strain NMI24_14

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LU682_RS01235 Protein ID WP_020190010.1
Coordinates 288388..288864 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q88R60
Locus tag LU682_RS01240 Protein ID WP_004575922.1
Coordinates 288906..289379 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU682_RS01215 (LU682_001215) 283531..284898 - 1368 WP_010951639.1 ATP-binding protein -
LU682_RS01220 (LU682_001220) 284900..285619 - 720 WP_010951640.1 response regulator -
LU682_RS01225 (LU682_001225) 285760..288057 + 2298 WP_010951641.1 TonB-dependent siderophore receptor -
LU682_RS01230 (LU682_001230) 288123..288329 - 207 WP_014860378.1 DUF3079 domain-containing protein -
LU682_RS01235 (LU682_001235) 288388..288864 + 477 WP_020190010.1 type II toxin-antitoxin system HigB family toxin Toxin
LU682_RS01240 (LU682_001240) 288906..289379 + 474 WP_004575922.1 transcriptional regulator Antitoxin
LU682_RS01245 (LU682_001245) 289384..289571 - 188 Protein_238 integrase -
LU682_RS01250 (LU682_001250) 289799..290014 + 216 WP_010951644.1 type II toxin-antitoxin system RelE/ParE family toxin -
LU682_RS01255 (LU682_001255) 290011..290334 - 324 WP_010951645.1 helix-turn-helix transcriptional regulator -
LU682_RS01260 (LU682_001260) 290900..293368 - 2469 WP_161989609.1 hypothetical protein -
LU682_RS01265 (LU682_001265) 293538..293813 - 276 WP_080516504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(114-152)

Antitoxin

Antitoxin HigA

(43-154)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18386.38 Da        Isoelectric Point: 10.3522

>T284831 WP_020190010.1 NZ_CP128540:288388-288864 [Pseudomonas alloputida]
MTGINPLAIARSPYIAHPDIWLTDIWIGDIFHPMLVRRDNTMRVITKAAVTKAIEVHGQWKAPLSLWLTTFDRATLRFES
FEQLRQTWATVSGWNVDRIPHSKLRPASRKGPLDIYVFDIKKNECRLIAWLNARTGTLYIKAILSHAEYDKWCRSDIR

Download         Length: 477 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17229.67 Da        Isoelectric Point: 4.4982

>AT284831 WP_004575922.1 NZ_CP128540:288906-289379 [Pseudomonas alloputida]
MKRDKIEANGLDAFIANISPMLDGLNTQMATMAQLLAACHDPIKDDAELEARMALIDELYSHADSEGHAAARFAEMVADR
VYEYESESVLVPFASQAEALAFLLSDRGVKQKDLSAIATQSAVSEILNNKRKMTVAQIKGFAEFFSVPVEFFMHGVV

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0CBJ4

References