Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2081511..2082161 Replicon chromosome
Accession NZ_CP128531
Organism Mannheimia haemolytica strain 120731

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag QTV67_RS10650 Protein ID WP_006249411.1
Coordinates 2081511..2081900 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D2Q6P1
Locus tag QTV67_RS10655 Protein ID WP_006251766.1
Coordinates 2081901..2082161 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV67_RS10605 2076991..2077800 - 810 WP_006250123.1 metal ABC transporter permease -
QTV67_RS10610 2077793..2078653 - 861 WP_061887112.1 metal ABC transporter permease -
QTV67_RS10615 2078727..2079512 - 786 WP_061887113.1 GDP-L-fucose synthase -
QTV67_RS10645 2080253..2081491 - 1239 WP_006251767.1 peptidase T -
QTV67_RS10650 2081511..2081900 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
QTV67_RS10655 2081901..2082161 - 261 WP_006251766.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QTV67_RS10660 2082277..2082489 - 213 WP_006251765.1 BrnA antitoxin family protein -
QTV67_RS10665 2082490..2082777 - 288 WP_006251764.1 BrnT family toxin -
QTV67_RS10670 2082940..2086473 - 3534 WP_006251763.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T284822 WP_006249411.1 NZ_CP128531:c2081900-2081511 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.50 Da        Isoelectric Point: 4.6909

>AT284822 WP_006251766.1 NZ_CP128531:c2082161-2081901 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A1D2Q6P1

References