Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 641177..641699 Replicon chromosome
Accession NZ_CP128531
Organism Mannheimia haemolytica strain 120731

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag QTV67_RS03265 Protein ID WP_006249269.1
Coordinates 641177..641473 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag QTV67_RS03270 Protein ID WP_006249270.1
Coordinates 641457..641699 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV67_RS03250 636231..637556 + 1326 WP_020831251.1 anti-phage deoxyguanosine triphosphatase -
QTV67_RS03255 637677..637976 + 300 WP_006249265.1 hypothetical protein -
QTV67_RS03260 638138..641050 + 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
QTV67_RS03265 641177..641473 + 297 WP_006249269.1 BrnT family toxin Toxin
QTV67_RS03270 641457..641699 + 243 WP_006249270.1 CopG family antitoxin Antitoxin
QTV67_RS03275 641711..642379 + 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QTV67_RS03280 642357..642932 - 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QTV67_RS03285 642992..643834 + 843 WP_006250575.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QTV67_RS03290 644012..645067 - 1056 WP_006251368.1 tyrosine-type recombinase/integrase -
QTV67_RS03295 645027..645302 - 276 WP_006248810.1 DUF4224 domain-containing protein -
QTV67_RS03300 645329..645820 - 492 WP_021279670.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T284819 WP_006249269.1 NZ_CP128531:641177-641473 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT284819 WP_006249270.1 NZ_CP128531:641457-641699 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References