Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2157739..2158389 Replicon chromosome
Accession NZ_CP128530
Organism Mannheimia haemolytica strain 131633

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag QTV58_RS11025 Protein ID WP_006249411.1
Coordinates 2157739..2158128 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D2Q6P1
Locus tag QTV58_RS11030 Protein ID WP_006251766.1
Coordinates 2158129..2158389 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV58_RS10980 2153219..2154028 - 810 WP_006250123.1 metal ABC transporter permease -
QTV58_RS10985 2154021..2154881 - 861 WP_061887112.1 metal ABC transporter permease -
QTV58_RS10990 2154955..2155740 - 786 WP_061887113.1 GDP-L-fucose synthase -
QTV58_RS11020 2156481..2157719 - 1239 WP_006251767.1 peptidase T -
QTV58_RS11025 2157739..2158128 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
QTV58_RS11030 2158129..2158389 - 261 WP_006251766.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QTV58_RS11035 2158505..2158717 - 213 WP_006251765.1 BrnA antitoxin family protein -
QTV58_RS11040 2158718..2159005 - 288 WP_006251764.1 BrnT family toxin -
QTV58_RS11045 2159168..2162701 - 3534 WP_006251763.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T284815 WP_006249411.1 NZ_CP128530:c2158128-2157739 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.50 Da        Isoelectric Point: 4.6909

>AT284815 WP_006251766.1 NZ_CP128530:c2158389-2158129 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A1D2Q6P1

References