Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1541959..1542555 Replicon chromosome
Accession NZ_CP128529
Organism Mannheimia haemolytica strain 132077

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QTV53_RS08085 Protein ID WP_006249776.1
Coordinates 1541959..1542183 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A547EKP0
Locus tag QTV53_RS08090 Protein ID WP_006249777.1
Coordinates 1542226..1542555 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV53_RS08065 1537840..1538742 - 903 WP_006249771.1 DMT family transporter -
QTV53_RS08070 1538739..1539095 - 357 WP_006249772.1 dihydroneopterin aldolase -
QTV53_RS08075 1539165..1539770 + 606 WP_006249773.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
QTV53_RS08080 1539844..1541751 - 1908 WP_006249774.1 DNA topoisomerase IV subunit B -
QTV53_RS08085 1541959..1542183 + 225 WP_006249776.1 type II toxin-antitoxin system HicA family toxin Toxin
QTV53_RS08090 1542226..1542555 + 330 WP_006249777.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QTV53_RS08095 1542594..1542980 - 387 WP_006249778.1 Cu(I)-responsive transcriptional regulator -
QTV53_RS08100 1543069..1543269 + 201 WP_006249779.1 heavy metal-associated domain-containing protein -
QTV53_RS08105 1543322..1545514 + 2193 WP_006249780.1 copper-translocating P-type ATPase -
QTV53_RS08110 1545567..1546352 - 786 WP_006249781.1 tRNA pseudouridine(38-40) synthase TruA -
QTV53_RS08115 1546417..1547106 - 690 WP_006253589.1 GTP cyclohydrolase I FolE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(28-73)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 10.5597

>T284806 WP_006249776.1 NZ_CP128529:1541959-1542183 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGR

Download         Length: 225 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12312.06 Da        Isoelectric Point: 4.7022

>AT284806 WP_006249777.1 NZ_CP128529:1542226-1542555 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A547EKP0

References