Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 470634..471156 Replicon chromosome
Accession NZ_CP128529
Organism Mannheimia haemolytica strain 132077

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag QTV53_RS02390 Protein ID WP_006249269.1
Coordinates 470634..470930 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag QTV53_RS02395 Protein ID WP_006249270.1
Coordinates 470914..471156 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV53_RS02375 465689..467014 + 1326 WP_006249264.1 anti-phage deoxyguanosine triphosphatase -
QTV53_RS02380 467135..467434 + 300 WP_006249265.1 hypothetical protein -
QTV53_RS02385 467595..470507 + 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
QTV53_RS02390 470634..470930 + 297 WP_006249269.1 BrnT family toxin Toxin
QTV53_RS02395 470914..471156 + 243 WP_006249270.1 CopG family antitoxin Antitoxin
QTV53_RS02400 471168..471836 + 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QTV53_RS02405 471814..472389 - 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QTV53_RS02410 472449..473291 + 843 WP_006249273.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QTV53_RS02415 473414..474055 + 642 WP_006249274.1 orotate phosphoribosyltransferase -
QTV53_RS02420 474229..475318 + 1090 Protein_459 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - htrB 336578..491885 155307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T284802 WP_006249269.1 NZ_CP128529:470634-470930 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT284802 WP_006249270.1 NZ_CP128529:470914-471156 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References