Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2123454..2124104 Replicon chromosome
Accession NZ_CP128527
Organism Mannheimia haemolytica strain 171096

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag QTV62_RS10970 Protein ID WP_006249411.1
Coordinates 2123454..2123843 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag QTV62_RS10975 Protein ID WP_006249412.1
Coordinates 2123844..2124104 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV62_RS10905 2118518..2119327 - 810 WP_006250123.1 metal ABC transporter permease -
QTV62_RS10910 2119320..2120180 - 861 WP_006250124.1 metal ABC transporter permease -
QTV62_RS10915 2120254..2121039 - 786 WP_006251768.1 hypothetical protein -
QTV62_RS10965 2122196..2123434 - 1239 WP_006253630.1 peptidase T -
QTV62_RS10970 2123454..2123843 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
QTV62_RS10975 2123844..2124104 - 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QTV62_RS10980 2124220..2124432 - 213 WP_006251765.1 BrnA antitoxin family protein -
QTV62_RS10985 2124433..2124720 - 288 WP_006251764.1 BrnT family toxin -
QTV62_RS10990 2124883..2128416 - 3534 WP_289333026.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T284790 WP_006249411.1 NZ_CP128527:c2123843-2123454 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT284790 WP_006249412.1 NZ_CP128527:c2124104-2123844 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References