Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1778957..1779479 Replicon chromosome
Accession NZ_CP128524
Organism Mannheimia haemolytica strain 181789

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag QTV56_RS09055 Protein ID WP_006249269.1
Coordinates 1779183..1779479 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag QTV56_RS09050 Protein ID WP_006249270.1
Coordinates 1778957..1779199 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV56_RS09025 1774795..1775884 - 1090 Protein_1740 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
QTV56_RS09030 1776058..1776699 - 642 WP_006249274.1 orotate phosphoribosyltransferase -
QTV56_RS09035 1776822..1777664 - 843 WP_006249273.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QTV56_RS09040 1777724..1778299 + 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QTV56_RS09045 1778277..1778945 - 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QTV56_RS09050 1778957..1779199 - 243 WP_006249270.1 CopG family antitoxin Antitoxin
QTV56_RS09055 1779183..1779479 - 297 WP_006249269.1 BrnT family toxin Toxin
QTV56_RS09060 1779606..1782518 - 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
QTV56_RS09065 1782679..1782978 - 300 WP_006249265.1 hypothetical protein -
QTV56_RS09070 1783099..1784424 - 1326 WP_006249264.1 anti-phage deoxyguanosine triphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T284763 WP_006249269.1 NZ_CP128524:c1779479-1779183 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT284763 WP_006249270.1 NZ_CP128524:c1779199-1778957 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References