Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2127956..2128606 Replicon chromosome
Accession NZ_CP128523
Organism Mannheimia haemolytica strain 182812

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag QTV55_RS10715 Protein ID WP_006249411.1
Coordinates 2127956..2128345 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D2Q6P1
Locus tag QTV55_RS10720 Protein ID WP_006251766.1
Coordinates 2128346..2128606 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV55_RS10670 2123436..2124245 - 810 WP_006250123.1 metal ABC transporter permease -
QTV55_RS10675 2124238..2125098 - 861 WP_061887112.1 metal ABC transporter permease -
QTV55_RS10680 2125172..2125957 - 786 WP_061887113.1 GDP-L-fucose synthase -
QTV55_RS10710 2126698..2127936 - 1239 WP_006251767.1 peptidase T -
QTV55_RS10715 2127956..2128345 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
QTV55_RS10720 2128346..2128606 - 261 WP_006251766.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QTV55_RS10725 2128722..2128934 - 213 WP_006251765.1 BrnA antitoxin family protein -
QTV55_RS10730 2128935..2129222 - 288 WP_006251764.1 BrnT family toxin -
QTV55_RS10735 2129385..2132918 - 3534 WP_006251763.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T284756 WP_006249411.1 NZ_CP128523:c2128345-2127956 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.50 Da        Isoelectric Point: 4.6909

>AT284756 WP_006251766.1 NZ_CP128523:c2128606-2128346 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A1D2Q6P1

References