Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 700312..700834 Replicon chromosome
Accession NZ_CP128523
Organism Mannheimia haemolytica strain 182812

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag QTV55_RS03555 Protein ID WP_006249269.1
Coordinates 700312..700608 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag QTV55_RS03560 Protein ID WP_006249270.1
Coordinates 700592..700834 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV55_RS03540 695366..696691 + 1326 WP_020831251.1 anti-phage deoxyguanosine triphosphatase -
QTV55_RS03545 696812..697111 + 300 WP_006249265.1 hypothetical protein -
QTV55_RS03550 697273..700185 + 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
QTV55_RS03555 700312..700608 + 297 WP_006249269.1 BrnT family toxin Toxin
QTV55_RS03560 700592..700834 + 243 WP_006249270.1 CopG family antitoxin Antitoxin
QTV55_RS03565 700846..701514 + 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QTV55_RS03570 701492..702067 - 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QTV55_RS03575 702127..702969 + 843 WP_006250575.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QTV55_RS03580 703147..704202 - 1056 WP_006251368.1 tyrosine-type recombinase/integrase -
QTV55_RS03585 704162..704437 - 276 WP_006248810.1 DUF4224 domain-containing protein -
QTV55_RS03590 704464..704955 - 492 WP_021279670.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 696812..752211 55399


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T284754 WP_006249269.1 NZ_CP128523:700312-700608 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT284754 WP_006249270.1 NZ_CP128523:700592-700834 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References