284750

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2098803..2099453 Replicon chromosome
Accession NZ_CP128522
Organism Mannheimia haemolytica strain 182963

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag QTV63_RS10665 Protein ID WP_006249411.1
Coordinates 2098803..2099192 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D2Q6P1
Locus tag QTV63_RS10670 Protein ID WP_006251766.1
Coordinates 2099193..2099453 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV63_RS10620 2094283..2095092 - 810 WP_006250123.1 metal ABC transporter permease -
QTV63_RS10625 2095085..2095945 - 861 WP_061887112.1 metal ABC transporter permease -
QTV63_RS10630 2096019..2096804 - 786 WP_061887113.1 GDP-L-fucose synthase -
QTV63_RS10660 2097545..2098783 - 1239 WP_006251767.1 peptidase T -
QTV63_RS10665 2098803..2099192 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
QTV63_RS10670 2099193..2099453 - 261 WP_006251766.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QTV63_RS10675 2099569..2099781 - 213 WP_006251765.1 BrnA antitoxin family protein -
QTV63_RS10680 2099782..2100069 - 288 WP_006251764.1 BrnT family toxin -
QTV63_RS10685 2100232..2103765 - 3534 WP_006251763.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T284750 WP_006249411.1 NZ_CP128522:c2099192-2098803 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.50 Da        Isoelectric Point: 4.6909

>AT284750 WP_006251766.1 NZ_CP128522:c2099453-2099193 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A1D2Q6P1

References