Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 700325..700847 Replicon chromosome
Accession NZ_CP128522
Organism Mannheimia haemolytica strain 182963

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag QTV63_RS03550 Protein ID WP_006249269.1
Coordinates 700325..700621 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag QTV63_RS03555 Protein ID WP_006249270.1
Coordinates 700605..700847 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV63_RS03535 695379..696704 + 1326 WP_020831251.1 anti-phage deoxyguanosine triphosphatase -
QTV63_RS03540 696825..697124 + 300 WP_006249265.1 hypothetical protein -
QTV63_RS03545 697286..700198 + 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
QTV63_RS03550 700325..700621 + 297 WP_006249269.1 BrnT family toxin Toxin
QTV63_RS03555 700605..700847 + 243 WP_006249270.1 CopG family antitoxin Antitoxin
QTV63_RS03560 700859..701527 + 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QTV63_RS03565 701505..702080 - 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QTV63_RS03570 702140..702982 + 843 WP_006250575.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QTV63_RS03575 703160..704215 - 1056 WP_006251368.1 tyrosine-type recombinase/integrase -
QTV63_RS03580 704175..704450 - 276 WP_006248810.1 DUF4224 domain-containing protein -
QTV63_RS03585 704477..704968 - 492 WP_021279670.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 696825..752304 55479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T284747 WP_006249269.1 NZ_CP128522:700325-700621 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT284747 WP_006249270.1 NZ_CP128522:700605-700847 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References