Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 395674..396196 Replicon chromosome
Accession NZ_CP128522
Organism Mannheimia haemolytica strain 182963

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QTV63_RS02060 Protein ID WP_040080572.1
Coordinates 395927..396196 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A248ZY54
Locus tag QTV63_RS02055 Protein ID WP_006250323.1
Coordinates 395674..395940 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV63_RS02035 391157..392197 - 1041 WP_147009503.1 IS481 family transposase -
QTV63_RS02040 392535..393920 - 1386 WP_006251981.1 GTPase HflX -
QTV63_RS02045 393940..394212 - 273 WP_006250326.1 RNA chaperone Hfq -
QTV63_RS02050 394281..395234 - 954 WP_040080573.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
QTV63_RS02055 395674..395940 + 267 WP_006250323.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QTV63_RS02060 395927..396196 + 270 WP_040080572.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
QTV63_RS02065 396215..398098 - 1884 WP_061887196.1 DNA mismatch repair endonuclease MutL -
QTV63_RS02070 398382..399620 + 1239 WP_061887197.1 glutamate-5-semialdehyde dehydrogenase -
QTV63_RS02075 399622..400467 + 846 WP_061887198.1 virulence factor BrkB family protein -
QTV63_RS02080 400442..400876 + 435 WP_006250318.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10508.09 Da        Isoelectric Point: 6.4732

>T284746 WP_040080572.1 NZ_CP128522:395927-396196 [Mannheimia haemolytica]
MREIEYSNAFKRDYKKCAVEFLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG

Download         Length: 270 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9738.10 Da        Isoelectric Point: 4.7954

>AT284746 WP_006250323.1 NZ_CP128522:395674-395940 [Mannheimia haemolytica]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZY54

References