Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 21603..22318 Replicon chromosome
Accession NZ_CP128522
Organism Mannheimia haemolytica strain 182963

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QTV63_RS00090 Protein ID WP_006250491.1
Coordinates 21603..22031 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag QTV63_RS00095 Protein ID WP_006248272.1
Coordinates 22031..22318 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV63_RS00075 16858..18510 + 1653 WP_040080487.1 phospho-sugar mutase -
QTV63_RS00080 18563..19496 + 934 Protein_15 nucleoside hydrolase -
QTV63_RS00085 19518..21599 - 2082 WP_040080489.1 ATP-dependent DNA helicase RecG -
QTV63_RS00090 21603..22031 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
QTV63_RS00095 22031..22318 - 288 WP_006248272.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
QTV63_RS00100 22482..24365 + 1884 WP_040080490.1 molecular chaperone HtpG -
QTV63_RS00105 24454..24600 + 147 WP_230269068.1 hypothetical protein -
QTV63_RS00110 24745..25785 + 1041 WP_021265350.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 24745..25785 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T284744 WP_006250491.1 NZ_CP128522:c22031-21603 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT284744 WP_006248272.1 NZ_CP128522:c22318-22031 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZW87

References