Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 24590..25305 Replicon chromosome
Accession NZ_CP128520
Organism Mannheimia haemolytica strain 191452

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QTV61_RS00100 Protein ID WP_006250491.1
Coordinates 24590..25018 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag QTV61_RS00105 Protein ID WP_006248272.1
Coordinates 25018..25305 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV61_RS00085 19844..21496 + 1653 WP_006248275.1 phospho-sugar mutase -
QTV61_RS00090 21549..22483 + 935 Protein_17 nucleoside hydrolase -
QTV61_RS00095 22505..24586 - 2082 WP_006248274.1 ATP-dependent DNA helicase RecG -
QTV61_RS00100 24590..25018 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
QTV61_RS00105 25018..25305 - 288 WP_006248272.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
QTV61_RS00110 25469..27352 + 1884 WP_006248270.1 molecular chaperone HtpG -
QTV61_RS00115 27405..27566 + 162 WP_015483997.1 hypothetical protein -
QTV61_RS00120 27730..29445 + 1716 WP_006248268.1 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T284735 WP_006250491.1 NZ_CP128520:c25018-24590 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT284735 WP_006248272.1 NZ_CP128520:c25305-25018 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZW87

References