Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1996877..1997399 Replicon chromosome
Accession NZ_CP128518
Organism Mannheimia haemolytica strain 192037

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag QTV60_RS10555 Protein ID WP_006249269.1
Coordinates 1997103..1997399 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag QTV60_RS10550 Protein ID WP_006249270.1
Coordinates 1996877..1997119 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV60_RS10525 1992715..1993804 - 1090 Protein_2035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
QTV60_RS10530 1993978..1994619 - 642 WP_006249274.1 orotate phosphoribosyltransferase -
QTV60_RS10535 1994742..1995584 - 843 WP_006249273.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QTV60_RS10540 1995644..1996219 + 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QTV60_RS10545 1996197..1996865 - 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QTV60_RS10550 1996877..1997119 - 243 WP_006249270.1 CopG family antitoxin Antitoxin
QTV60_RS10555 1997103..1997399 - 297 WP_006249269.1 BrnT family toxin Toxin
QTV60_RS10560 1997526..2000438 - 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
QTV60_RS10565 2000599..2000898 - 300 WP_006249265.1 hypothetical protein -
QTV60_RS10570 2001019..2002344 - 1326 WP_006249264.1 anti-phage deoxyguanosine triphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T284724 WP_006249269.1 NZ_CP128518:c1997399-1997103 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT284724 WP_006249270.1 NZ_CP128518:c1997119-1996877 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References