Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 1620195..1620835 | Replicon | chromosome |
| Accession | NZ_CP128518 | ||
| Organism | Mannheimia haemolytica strain 192037 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A378NFX7 |
| Locus tag | QTV60_RS08505 | Protein ID | WP_006250075.1 |
| Coordinates | 1620195..1620377 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A378NFW9 |
| Locus tag | QTV60_RS08510 | Protein ID | WP_006250074.1 |
| Coordinates | 1620416..1620835 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QTV60_RS08465 | 1615332..1615631 | + | 300 | WP_006247810.1 | XRE family transcriptional regulator | - |
| QTV60_RS08470 | 1615748..1616788 | + | 1041 | WP_015587043.1 | IS481 family transposase | - |
| QTV60_RS08475 | 1616848..1617006 | - | 159 | WP_006247809.1 | hypothetical protein | - |
| QTV60_RS08480 | 1617016..1618083 | - | 1068 | WP_006253284.1 | hypothetical protein | - |
| QTV60_RS08485 | 1618104..1618304 | - | 201 | WP_006248825.1 | YdaS family helix-turn-helix protein | - |
| QTV60_RS08490 | 1618435..1619118 | + | 684 | WP_006248824.1 | S24 family peptidase | - |
| QTV60_RS08495 | 1619193..1619573 | + | 381 | WP_006248823.1 | hypothetical protein | - |
| QTV60_RS08500 | 1619566..1620063 | + | 498 | WP_006250077.1 | hypothetical protein | - |
| QTV60_RS08505 | 1620195..1620377 | + | 183 | WP_006250075.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| QTV60_RS08510 | 1620416..1620835 | + | 420 | WP_006250074.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| QTV60_RS08515 | 1621171..1621815 | + | 645 | WP_006253274.1 | tyrosine-type recombinase/integrase | - |
| QTV60_RS08520 | 1621953..1622993 | + | 1041 | WP_015587023.1 | IS481 family transposase | - |
| QTV60_RS08525 | 1623060..1624466 | - | 1407 | WP_006253513.1 | YdgA family protein | - |
| QTV60_RS08530 | 1624516..1625322 | - | 807 | WP_006248821.1 | tryptophan synthase subunit alpha | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1554789..1678418 | 123629 | |
| - | flank | IS/Tn | - | - | 1615748..1616788 | 1040 | |
| - | flank | IS/Tn | - | - | 1621953..1622993 | 1040 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6933.03 Da Isoelectric Point: 10.3446
>T284723 WP_006250075.1 NZ_CP128518:1620195-1620377 [Mannheimia haemolytica]
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
MKYSEFLRYLLAQGCEIENHRRGSHRKVTLNGKQSVFPYHGSKEIGTGLVNKIKKDLDLK
Download Length: 183 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15938.30 Da Isoelectric Point: 4.6963
>AT284723 WP_006250074.1 NZ_CP128518:1620416-1620835 [Mannheimia haemolytica]
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQHFTILPH
MLRYPVEITPDDNGTYLVTCPDIPEMASVGEDLEEALLEAQDGLATALEFYFDDRREIPMPSPIKEGQHTVNLTVLQSMK
VFLLNEMIKQGVRKAEMARRLDVHLPQIDRLLDFNHSTKVEFVEKAYGKLNQHFTILPH
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NFX7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378NFW9 |